Strain Name:
STOCK Del(11Mpo-Chad)18Brd Dp(11Mpo-Chad)18Brd/Mmucd
Stock Number:
030221-UCD
Citation ID:
RRID:MMRRC_030221-UCD
Other Names:
Dp(11)18/Df(11)18, B6;129S7-Del(11Mpo-Chad)18Brd Dp(11Mpo-Chad)18Brd/Mmcd

Strain Information

Del(11Mpo-Chad)18Brd
Name: deletion, Chr 11, Bradley 18; deletion, Chr 11, Allan Bradley 18
Synonyms: Del18Brd, Df(11)18
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Deletion
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Deletion
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Chad
Name: chondroadherin
Synonyms: SLRR4A
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Deletion
NCBI: 12643
HGNC: HGNC:1909
Homologene: 36063
Dp(11Mpo-Chad)18Brd
Name: duplication, Chr 11, Bradley 18; duplication, Chr 11, Allan Bradley 18
Synonyms: Dup(11)(Mpo-Chad)Brd, Dp(11)18
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Duplication
Genetic Alterations
A 6.9-Mb deletion and reciprocal duplication on Chr11, spanning genes Mpo to Chad.
Genotype Determination
ES Cell Line
AB2.2 derived from 129S7/SvEvBrd-Hprtb-m2
Phenotype
Homozygous: Dp(11)18/Dp(11)18 causes embryonic or adolescent lethality. Df(11)18/Df(11)18 is embryonic lethal.

Heterozygous: Df(11)18/+ causes cardiovascular abnormalities.
Mammalian Phenotype Terms
Allelic Composition: Del(11Mpo-Chad)18Brd/Del(11Mpo-Chad)18Brd (Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 )

Allelic Composition: Del(11Mpo-Chad)18Brd/+ (Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 )

Allelic Composition: Dp(11Mpo-Chad)18Brd/Dp(11Mpo-Chad)18Brd (Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 )

MeSH Terms
  • Animals
  • Cardiovascular Abnormalities/genetics
  • Chromosome Deletion
  • Chromosomes, Human, Pair 17/genetics
  • Chromosomes, Mammalian/genetics
  • Fetal Death/genetics
  • Gene Duplication
  • Genetic Markers/genetics
  • Genome/genetics
  • Genotype
  • Heart Defects, Congenital/genetics
  • Homeodomain Proteins/genetics
  • Humans
  • Mice
  • Recombination, Genetic
  • Sequence Homology, Nucleic Acid
  • Survival Rate
  • Synteny/genetics
  • Animals, Newborn
  • Embryo, Mammalian/drug effects
  • Embryonic Development/genetics
  • Genes, BRCA1
  • Genes, Lethal
  • Genetic Complementation Test
  • Gestational Age
  • Homozygote
  • Mice, Mutant Strains/genetics
  • Mutagenicity Tests/methods
  • Mutation
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Cardiovascular
  • Developmental Biology
  • Internal/Organ
  • Models for Human Disease
  • Reproduction
  • Research Tools
Donor
Allan Bradley, Ph.D., Wellcome Trust Sanger Institute.
Primary Reference

Yu YE, Morishima M, Pao A, Wang DY, Wen XY, Baldini A, Bradley A. A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics. 2006 May;173(1):297-307. Epub 2006 Feb 19. (Medline PMID: 16489219)

Hentges KE, Nakamura H, Furuta Y, Yu Y, Thompson DM, O'Brien W, Bradley A, Justice MJ. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns. 2006 Aug;6(6):653-65. Epub 2006 Feb 8. (Medline PMID: 16466971)

Colony and Husbandry Information

Note - per PMID:16489219, 129S5 is involved as well: "The vectors from both libraries contain inserts of DNA that were generated by partial Sau3AI digestion of genomic DNA from the 129S5 mouse strain.". Since more than 2 inbred lines are mixed (C57BL/6J, 129S5, 129S7), STOCK designation is warranted.

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
Coat Color
Cream or black
Eye
Dark
MMRRC Breeding System
Sib-mating
Overall Breeding Performance
Excellent
Viability and Fertility: Female Male Comments
Homozygotes are viable: No No
Homozygotes are fertile: No No
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: 6 months 8 months
Average litter size
8
Recommended wean age
3 weeks
Average Pups Weaned
8

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
030221-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
030221-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.