Loading Mouse GIF
Loading...

Strain Name:
SSIN/BenaMmucd
Stock Number:
034297-UCD
Citation ID:
RRID:MMRRC_034297-UCD

Strain Information

Genetic Alterations
None. Inbred strain derived by selection for sensitivity to a two-stage carcinogenesis protocol.
Genotype Determination

Phenotype
SSIN mmice show a dissociation between susceptibility to papilloma development and the malignant conversion of these into SSIN shows a dissociation between susceptibility to papilloma development and the malignant conversion of these into squamous cell carcinomas.
MeSH Terms
  • Animals
  • Diterpenes
  • Female
  • Histocompatibility Testing
  • Mice
  • Mice, Inbred Strains/physiology
  • Ornithine Decarboxylase/metabolism
  • Skin/drug effects
  • Skin/enzymology
  • Skin Neoplasms/chemically induced
  • Skin Neoplasms/pathology
  • Skin Transplantation
  • Terpenes/pharmacology
  • Tetradecanoylphorbol Acetate/toxicity
  • 9,10-Dimethyl-1,2-benzanthracene
  • Carcinoma, Squamous Cell/chemically induced
  • Dose-Response Relationship, Drug
  • Mice, Inbred SENCAR
  • Papilloma/chemically induced
  • Tetradecanoylphorbol Acetate
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Submitter
Fernando Benavides, DVM, Ph.D. University of Texas MD Anderson Cancer Center
Primary Reference
  • Fischer SM; O'Connell JF; Conti CJ; Tacker KC; Fries JW; Patrick KE; Adams LM; Slaga TJ, Characterization of an inbred strain of the SENCAR mouse that is highly sensitive to phorbol esters., Carcinogenesis. 1987 Mar;8(3):421-4. (Medline PMID: 3545526)
  • Coghlan LG; Gimenez-Conti I; Kleiner HE; Fischer SM; Rundhaug JE; Conti CJ; Slaga TJ; DiGiovanni J, Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis., Carcinogenesis. 2000 Apr;21(4):641-6. (Medline PMID: 10753198)
Strain Development
This inbred strain is one of the nine different strains derived from outbred SENCAR mice. Interestingly, these strains display different sensitivities to two-stage carcinogenesis. Fisher et al. developed the strain SSIN/Sprd by selecting, for 9 generations, the mice that were most sensitive to a two-stage carcinogenesis protocol. The number of papillomas in the SSIN strain is 3- fold higher than in the SENCAR outbred mice but, at the same time, this strain is very resistant to tumor progression.

Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain's tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
034297-UCD-RESUS Litter recovered from cryo-archive $5,892.91 / $6,181.91
Non-Profit / For-Profit
Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.