Strain Name:
GlndMmucd:HVWR6
Stock Number:
036757-UCD
Citation ID:
RRID:MMRRC_036757-UCD
Other Names:
HR6, High Runner 6

Strain Information

Myh4minimsc
Name: myosin, heavy polypeptide 4, skeletal muscle; mini muscle
Type: QTL
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Polymorphic allele
Genetic Alterations

Selectively Bred. This line is segregating for the mini muscle mutation, Myh4minimsc

Phenotype
High voluntary wheel-running. High Runner 7 lacks the mini-muscle phenotype seen in lines High Runner 3 (MMRRC:36756) and High Runner 6 (MMRRC:36757). HR7 also exhibits several differences from High Runner 8 (MMRRC:36759) in open-field behavior and behavior in a plus-maze.
MeSH Terms
  • Analysis of Variance
  • Animals
  • Crosses, Genetic
  • Female
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity/genetics
  • Regression Analysis
  • Selection, Genetic
Strain Development
Replicated within-family selection for increased voluntary wheel-running in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied with four high-selected and four control lines (10 families/line).
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Diabetes/Obesity
  • Metabolism
  • Models for Human Disease
    • ADHD
  • Neurobiology
  • Exercise physiology
Donor
Theodore Garland, Ph.D., University of California, Riverside.
Primary Reference

Swallow JG, Carter PA, Garland T Jr. Artificial selection for increased wheel-running behavior in house mice. Behav Genet. 1998 May;28(3):227-37. (Medline PMID: 9670598)

I. Jonas, K. A. Schubert, A. C. Reijne, J. Scholte, T. Garland, Jr, M. P. Gerkema, A. J. W. Scheurink, C. Nyakas, and G. van Dijk. Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice. Behav Genet. 2010 Jul; 40(4): 542-550. (Medline PMC: 2886896)

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
Coat Color
White
Eye
Red
MMRRC Breeding System
Selectively bred for high voluntary wheel-running.
Breeding Scheme(s)

Within-family selection

Generation
S65+
Overall Breeding Performance
Good
Bred to Homozygosity
No
Average litter size
10-14
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
036757-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / $7,650.23
Non-Profit / For-Profit
Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.