Strain Detail Sheet

Strain Name:
Hairless-2
Stock Number:
037615-MU
Citation ID:
RRID:MMRRC_037615-MU
Major Collection:
Peromyscus Mice

Strain Information

Gene Details

Genotype Determination

Strain Description

Phenotype

Homozygous: adults are virtually nude except for vibrissae and sensitive hairs which exist as short stumps. Some individuals have normal shaped, but short vibrissae. The trait can be detected in newborn deer mice by the twisted appearance of the vibrissae. Animals begin to lose hair about twelve days of age, following a period during which the coat has a distinctive sheen. Juveniles have dark pigmented bodies with pink faces. Transient coats appear at subadult and adult molts. The deer mice are most readily distinguished from hairless-1 by the absence of elongate claws. Scanning electromicroscopy reveals many hairs that are abnormally twisted or bilobar, and that are fragile and readily break off at the skin surface. Ears of homozygous hairless-2 deer mice are abnormally thin and there is a general reduction in body weight.

Heterozygous: hairless-2 deer mice have full pelage, but the coat has a greasy texture.

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Strain Origin

Donor
Michael Felder, The Peromyscus Genetic Stock Center, University of South Carolina.
Primary Reference

For more information, please see Hairless-2 on the Peromyscus Genetic Stock Center website.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu

Appearance

Coat Color
Homozygous (hr-2/hr-2) have no hair except for very short vibrissae and claws tend to elongate.

Heterozygous (hr-2/+) are the same as wild-type.

Breeding

MMRRC Breeding System
Not applicable; only cryopreserved sperm is available. The parent colony was sufficiently large to use a random breeding scheme
Breeding Scheme(s)
Not applicable; only cryopreserved sperm is available; mice cryorecovered (see below) can be bred Wild-type female x Wild-type male
Overall Breeding Performance
Peromyscus mice breed best in a 16:8 light / dark cycle.

Reproductive Statistics

Average litter size
4.4
Recommended wean age
25 days

Order Request Information

Availability Level

Male mice were obtained from the Peromyscus Genetic Stock Center as part of a long term project to develop cropreservation techniques for Peromyscus. Sperm have been cryopreserved and are available. However, cryorecovery techniques have yet to be developed.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.