Register New MMRRC Account
Reset Password
Register for New Mouse Models
Click Here for Additional Contact Information
Availability & Fees Order this Strain
Duffield GE, Robles-Murguia M, Watson NP, Mantani A, Peirson SN, Loros JJ, Israel MA, Dunlap JC. A role for the Id2 gene in regulating photic entrainment of the mammalian circadian system. Curr Biol. 2009 Feb 24;19(4):297-304. Epub 2009 Feb 12. (Medline PMID: 19217292)
Hou TY, Ward SM, Murad JM, Watson NP, Israel MA, and Duffield GE. Inhibitor of DNA binding 2 (ID2) is a rhythmically expressed transcriptional repressor required for circadian clock output in the mouse liver. J Biol Chem. 2009 Nov 13;284(46):31735-45. Epub 2009 Sep 9. (Medline PMID: 19740747)
Havrda MC, Harris BT, Mantani A, Ward NM, Paolella BR, Cuzon VC, Yeh HH, Israel MA. Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. J Neurosci. 2008 Dec 24;28(52):14074-86. (Medline PMID: 19109490)
Ward SM, Fernando S, Hou TY, Duffield GE. 2010. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010 Dec 10;285(50):38987-9000. Epub 2010 Sep 22. (Medline PMID: 20861012)
Mathew D, Zhou P, Pywell CM, Van der Veen DR, Shao J, Xi Y, Bonar NA, Hummel A, Chapman S, Leevy WM, Duffield GE. 2013. Ablation of the Id2 gene results in altered circadian feeding behavior, and sex-specific enhancement of insulin sensitivity and elevated glucose uptake in skeletal muscle and brown adipose tissue. PLoS One. 2013 Sep 2;8(9):e73064. (Medline PMID: 24023810)
Zhou P, Hummel AD, Pywell CM, Dong XC, Duffield GE. 2014. High fat diet rescues disturbances to metabolic homeostasis and survival in the Id2 null mouse in a sex-specific manner. Biochem Biophys Res Commun. 2014 Aug 29;451(3):374-81. Epub 2014 Aug 7.(Medline PMID: 25108156)
Metzinger M, Miramontes B, Zhou P, Liu Y, Peng J, Chapman S, Sun L, Sasser TA, Duffield GE, Stack MS, Leevy WM. 2014. Correlation of X-ray Computed Tomography with Quantitative Nuclear Magnetic Resonance (QMR) Methods for Pre-Clinical Measurement of Adipose and Lean Tissues in Living Mice. Sensors (Basel). 2014 Oct 8;14(10):18526-42. (Medline PMID: 25299952)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.