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Availability & Fees Order this Strain
QTL Burly1 was created in the donor's laboratory by introducing a donor chromosomal fragment from 129P3/J (JAX Stock #000690; donor strain) into the genetic background of C57BL/6ByJ (JAX Stock #001139). The donor fragment captures the lean body mass QTL1, Burly1.
Homozygous: The phenotype for this mouse strain is abnormal lean body mass [MP:0003959]. Mice with the Burly1-129 allele have heavier lean body mass than mice with the Burly1-B6 allele.
Hetero/Hemizygous: Burly1 -B6 allele is dominant. Therefore, mice with the one or two Burly1 129 alleles have heavier lean body mass than mice with two Burly B6 alleles.
Cre-excised Phenotype: Undetermined
Reed DR, Li X, McDaniel AH, Lu K, Li S, Tordoff MG, Price RA, Bachmanov AA.Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposityidentified in a genome scan of an F2 intercross between the 129P3/J andC57BL/6ByJ mouse strains. Mamm Genome. 2003 May;14(5):302-13. (Medline PMID: 12856282)
Lin C, Fesi BD, Marquis M, Bosak NP, Theodorides ML, Avigdor M, McDaniel AH,Duke FF, Lysenko A, Khoshnevisan A, Gantick BR, Arayata CJ, Nelson TM, Bachmanov AA, Reed DR. Body Composition QTLs Identified in Intercross Populations AreReproducible in Consomic Mouse Strains. PLoS One. 2015 Nov 9;10(11):e0141494.doi: 10.1371/journal.pone.0141494. eCollection 2015. (Medline PMID: 26551037)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.