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Homozygous: NA
Hemizygous: High bone mass
O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008 Aug 13;3(8):e2942. doi: 10.1371/journal.pone.0002942. (Medline PMID: 18698360)
O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, RoblingAG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC,Bellido T. Control of bone mass and remodeling by PTH receptor signaling inosteocytes. PLoS One. 2008 Aug 13;3(8):e2942. doi: 10.1371/journal.pone.0002942. (Medline PMID: 18698360)
1) Rhee Y, Allen MR, Condon K, Lezcano V, Ronda AC, Galli C, Olivos N, Passeri G, O’Brien CA, Bivi N, Plotkin LI, Bellido T. PTH receptor signaling in osteocytes governs periosteal bone formation and intra-cortical remodeling. Journal of Bone and Mineral Research, 26 (5): 1035-1046, 2011. doi:10.1002/jbmr.3042) Rhee Y, Farrow E, Bivi N, Lezcano V, Plotkin LI, White KE, Bellido T. Parathyroid hormone controls the endocrine and auto/paracrine function of osteocytes by upregulating the expression of fibroblast growth factor-23. Bone, 49:636-643, 2011. doi:10.1016/j.bone.2011.06.0253) Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T. Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells. Blood, 119:2489-2499, 2012.4) Rhee Y, Lee E-Y, Lezcano V, Ronda AC, Allen MR, Plotkin LI, Bellido T. Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes. Journal of Biological Chemistry, 288:29809-29820, 2013; doi: 10.1074/jbc.M113.4859385) Ben-Awadh A, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology, 155:2797-2809, 2014
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.