• BayGenomics ES Cell Lines

• Beta Cell Biology Consortium Collection

• Beutler Strains

• Comparative Mouse Genomics Centers Consortium

• Deltagen

• Gene Expression Nervous System Atlas

• Lexicon Pharmaceuticals

• Mammalian Pigmentation

• Mutagenesis for Dev. Defects/Baylor

• Nagy Basic ES Cell Lines

• Sanger Gene Trap ES Cell Lines

• Soriano Gene Trap ES Cell Lines

• UNC Mutagenized ES Cell Lines

• ES Cell Line Information

Beutler Strains

Information excerpted from the MUTAGENETIX website; additional information can be found there.

Background

Beutler Strains are from the MUTAGENETIX archive of phenotypes and mutations produced in Dr. Bruce Beutler’s Lab (Department of Genetics, The Scripps Research Institute). They have been produced through random germline mutagenesis with ENU. Where possible, value is added by focusing on sets of genes that serve related biological functions, and offering insight into the mechanism by which phenotypes arise.

G1 and G3 mutant mice are actively screened for immunological phenotypes. However, many non-immunological phenotypes are incidentally identified, and some of them address major biological questions. Mutations are positionally cloned more rapidly than they can be investigated in depth, and in many cases, more rapidly than they can be published in conventional journals. Therefore, all mutations are described on the MUTAGENETIX website, as to the essential phenotypic characteristics and availability.

All information on chromosomal locations and critical region intervals are currently based on Ensembl Mouse annotation (release 48). Specific sequence information (gene sequences, positions of mutations, etc.) is based on the NCBI m37 mouse assembly (Build 37.1). Individual strain records on the MUTAGENETIX website contain links to specific cDNA sequences and/or genomic DNA sequences in the NCBI database.

MMRRC holdings

The MMRRC holds over 50 mutant strains in this collection and the number continues to grow.

Distribution

Strains are distributed using the MMRRC Conditions of Use *(COU). Mice are available only to investigators at not-for-profit institutions.

* The preceding link is to the COU text only; the COU user form will be provided after order submission.

Citations

MUTAGENETIX, in journal articles or on-line publications, should be cited using the following conventions: {Authors}. Record for {allele name}, updated {date of last update}. MUTAGENETIX (TM), B. Beutler and colleagues, Department of Genetics, The Scripps Research Institute, La Jolla, CA. Accessed {date of download}. World Wide Web URL: http://mutagenetix.scripps.edu/

Related Links

• MMRRC catalog of all Beutler lines
• MUTAGENETIX website