• BayGenomics ES Cell Lines

• Beta Cell Biology Consortium Collection

• Beutler Strains

• Comparative Mouse Genomics Centers Consortium

• Deltagen

• Gene Expression Nervous System Atlas

• Lexicon Pharmaceuticals

• Mammalian Pigmentation

• Mutagenesis for Dev. Defects/Baylor

• Nagy Basic ES Cell Lines

• Sanger Gene Trap ES Cell Lines

• Soriano Gene Trap ES Cell Lines

• UNC Mutagenized ES Cell Lines

• ES Cell Line Information

Comparative Mouse Genomics Centers Consortium (CMGCC)

Information excerpted from the CMGCC website; additional information can be found there.

Background

The Comparative Mouse Genomics Centers Consortium (CMGCC) was initiated by the National Institute of Environmental Health Sciences’ (NIEHS) Environmental Genome Project to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes. These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges. This program has resulted in the discovery of unique variants in environmentally responsive genes, the development of a number of resources, and capacity building in the environmental epidemiology communities in order to incorporate gene-environment hypotheses and tools into human population-based studies on a number of environmentally relevant diseases. This Consortium requires extensive collaboration and multidisciplinary research in molecular biology, biochemistry, structural biology, as well as expertise in mouse genetics and pathology, to achieve the following goals:

• Identify relevant and feasible mouse models for development by the Consortium;
• Identify mouse models that are relevant to human environmental health; and
• Validate developed mouse models that are relevant to environmentally induced human diseases.

MMRRC holdings

The models developed by the Consortium are being made available to the scientific community through an arrangement with the National Center for Research Resources (NCRR). The MMRRC holds over 20 transgenic and knockout strains in this collection.

Distribution

Strains are distributed using the MMRRC Conditions of Use *(COU). Mice are available only to investigators at not-for-profit institutions.

* The preceding link is to the COU text only; the COU user form will be provided after order submission.

Related Links

• MMRRC catalog of all CMGCC lines
• CMGCC website