• BayGenomics ES Cell Lines

• Beta Cell Biology Consortium Collection

• Beutler Strains

• Comparative Mouse Genomics Centers Consortium

• Deltagen

• Gene Expression Nervous System Atlas

• Lexicon Pharmaceuticals

• Mammalian Pigmentation

• Mutagenesis for Dev. Defects/Baylor

• Nagy Basic ES Cell Lines

• Sanger Gene Trap ES Cell Lines

• Soriano Gene Trap ES Cell Lines

• UNC Mutagenized ES Cell Lines

• ES Cell Line Information

Mutagenesis for Developmental Defects / Baylor

Information excerpted from the Mouse Mutagenesis Center for Developmental Defects website; additional information may be found there.

Background

The goal of the ENU Mutagenesis project is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chromosome 11 exhibits linkage conservation with human Chromosome 17. The chemical N-ethyl-N-nitrosourea (ENU) was used to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, extrapolation leads to predicting function on a human chromosome. Many of the new mutants are expected to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations expected to be isolated may be lethal or detrimental to the mice, a unique approach to isolate mutations is used. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval.

MMRRC holdings

The MMRRC holds over 30 strains in this collection.

Distribution

Strains are distributed using the MMRRC Conditions of Use *(COU). Mice are available only to investigators at not-for-profit institutions.

* The preceding link is to the COU text only; the COU user form will be provided after order submission.

Related Links

• MMRRC catalog of all Mutagenesis for Dev. Defects/Baylor lines
• Mouse Mutagenesis Center for Developmental Defects website