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Allele Symbol: Tlr6int Name: toll-like receptor 6 / insouciant Alteration at locus: Induced Mutation |
Phenotype:
Homozygous phenotype: Macrophages show no response to TLR2/6 ligands
Heterozygous phenotype: Normal as wild type
Mammalian Phenotype Terms:
assigned by genotype
Strain Type:
Founder genetic background: C57BL/6J
Strain genetic background: C57BL/6J
Strain Development:
Homozygous mutant was picked up by the screening, and backcrossed to its parents,
after that homozygotes were kept by sib-mating.
Donor: Bruce Beutler, M.D., The Scripps Research Institute
Primary Reference:
Zhengfan Jiang, Philippe Georgel, Chenglong Li, Jungwoo Choe, Karine Crozat, Sophie Rutschmann, Xin Du, Tim Bigby, Suzanne Mudd, Sosathya Sovath, Ian A. Wilson, Arthur Olson, and Bruce Beutler. Details of Toll-like receptor:adapter interaction revealed by germline mutagenesis. [Submitted]
For additional information, please see: Mutagenetix, a catalogue of mutations identified in the Beutler Laboratory at The Scripps Research Institute.
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Mice recovered from a cryo-archive will have health surveillance performed on the
resuscitated animals.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
* Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
Click button to Request this one strain.
(Use the MMRRC
Catalog Search to request more than one strain.)
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Distribution Fee/unit (US $) |
Units | Notes | ||||
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Litter | Recovered litter1; additional fees for any special requests. | ||||
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Aliquot | Approximate quantity.2 | ||||
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Aliquot | Approximate quantity3: 20-40 embryos / aliquot | ||||
1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one breedable mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains sufficient material (volume and concentration) for at least two IVF or several artificial inseminations (based on our procedures). The MMRRC makes no guarantee concerning success of these procedures when performed outside the MMRRC facilities.
3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the "Request this Strain" button above). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (207) 288-6009 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to information.
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Last Modified: June 23, 2010