Strain Detail Sheet

Phenotype:
The JU background influences the size and locations of white spots (areas where pigment cells are absent), in differing ways, compared with the C57BL/6J background, when combined with specific white-spotting mutant alleles. The JU background also strongly affects the phenotype of mice mutant at the agouti locus, compared with C57BL/6J mice, but increasing the amount of eumelanin in the coat.

This inbred strain is the background strain and the most appropriate control strain for several other MMRRC strains from the donor's collection. Specifically:

• MMRRC:000155
• MMRRC:000172
• MMRRC:000177
• MMRRC:000178
• MMRRC:000180
• MMRRC:000221
• MMRRC:000359

Strain Type: Inbred

Founder genetic background: Mixed (see strain development)

Strain genetic background: JU/CtLm

Strain Development:
Dr. Falconer originally created this strain by crossing several other strains, including C57BL. Dr. Cattanach obtained this stock with albino (mutant tyrosinase) from Falconer in 1966. He subsequently removed the albino allele and in 1973 transfer the strain to Dr. Lamoreux, who subsequently maintained it by brother/sister matings. (Please see MGD's Festing's Inbred Strains of Mice for additional information.)

• Inbred control strain for JU/CtLm derived strains
• Study of the genetic control of background genome over the expression of phenotypes determined at loci where the genotype is not different.

Donor: Dr. ML Lamoreux, Texas A&M University

Primary Reference:

Lamoreux ML, Wakamatsu K, Ito S. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res. 2001 Feb;14(1):23-31. (Medline PMID: 11277491)

Lamoreux ML. Strain-specific white-spotting patterns in laboratory mice. Pigment Cell Res. 1999 Dec;12(6):383-90. (Medline PMID: 10614578)

Lamoreux ML. The inbred mouse in pigmentation research: significance of a congenic developmental system. Pigment Cell Res. 2000 Dec;13(6):421-30. Review. (Medline PMID: 11153693)

Coat color: Black

Other:

MMRRC Breeding System: Sib or Intra-strain mating

Breeding Scheme(s):

• Homozygous female x Homozygous male

Generation: F20+

Overall Breeding Performance: Good

This inbred strain is not intended for breeding except as backcross strain to maintain derived strains in heterozygous state and as experimental controls for those derived strains.

* Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item #	Description	Distribution Fee/unit (US $)	Units
000136-MU-RESUS	Resuscitation from cryopreserved material	$1,963.00	litter a
000136-MU-SPERM	Cryopreserved spermatozoa	$424.00	aliquot b
000136-MU-EMBRYO	Cryopreserved embryo	$1,008.00	aliquot c

^a The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one breedable mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC repository will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC repository.

^b An aliquot contains sufficient material (volume and concentration) for at least two IVF or several artificial inseminations (based on our procedures). The MMRRC makes no guarantee concerning success of these procedures when performed outside the MMRRC facilities.

^c An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.