Strain Name: B6;129-Dnmt3atm1Jae/Mmnc
Stock Number: 031042-UNC
Other Names:
- Dnmt3a2Lox
Gene Details: (provided by MGI)
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Allele Symbol: Dnmt3atm1Jae Name: DNA methyltransferase 3A; targeted mutation 1, Rudolf Jaenisch Alteration at locus: Targeted Mutation |
Strain Description
Phenotype:
Homozygous phenotype: Conditional
mutation, loop out in brain leads to neuromuscular defects and shortened
life span
Heterozygous phenotype: Conditional
mutation, loop out in brain leads to neuromuscular defects and shortened
life span
Founder genetic background: 129 / C57BL/6 intercross
Strain genetic background: Mixed, 129 x B6 inter breeding
Strain Development:
Research Applications
- Cancer
- Cell Biology
- Models for Human Disease
- Neurobiology
Strain Origin
Donor: Rudolf Jaenisch, Ph.D., Whitehead Institute
Primary Reference:
Nguyen S; Meletis K; Fu D; Jhaveri S; Jaenisch R, Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan., Dev Dyn 2007 Jun;236(6):1663-76 (Medline PMID: 17477386)
Special Considerations
Health Status Report
Mice recovered from a cryo-archive will have health surveillance performed on the resuscitated animals.
Order Request Information
Availability Level:
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Conditions of Distribution:
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Fees:
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
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Click button to Request this one strain.
(Use the MMRRC Catalog Search to request more than one strain.) | |||||||
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Distribution Fee/unit (US $) |
Units | Notes | ||||
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Litter | Recovered litter1; additional fees for any special requests. | ||||
1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one breedable mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains sufficient material (volume and concentration) for at least two IVF or several artificial inseminations (based on our procedures). The MMRRC makes no guarantee concerning success of these procedures when performed outside the MMRRC facilities.
3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the "Request this Strain" button above). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (International calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.
