Strain Detail Sheet

Phenotype:
Dysmyelination

Strain Type: Mixed Inbred Targeted Mutation/Knockout

Founder genetic background: B6;129S

Strain genetic background: Mixed Inbred B6;129

Strain Development:
ES cells were injected into C57BL/6; founder offspring were selected and bred to homozygosity.

• Neurology

Donor: Dr. Richard Proia, NIDDK, NIH, DHHS

Primary Reference:

Liu Y, Wada R, Kawai H, Sango K, Deng C, Tai T, McDonald MP, Araujo K, Crawley JN, Bierfreund U, Sandhoff K, Suzuki K, Proia RL. A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest. 1999 Feb;103(4):497-505. (Medline: 10021458)

Coat color: Variable

Other:

MMRRC Breeding System: Sib Mating

Breeding Scheme(s):

• Heterozygous female x Heterozygous male
• Homozygous female x Heterozygous male

Generation: Unknown

Overall Breeding Performance: Unknown

None

* Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item #	Description	Distribution Fee/unit (US $)	Units
000036-MU-RESUS	Resuscitation from cryopreserved material	$1,906.00	litter a
000036-MU-SPERM	Cryopreserved spermatozoa	$412.00	aliquot b
000036-MU-EMBRYO	Cryopreserved embryo	$979.00	aliquot c

^a The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one breedable mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC repository will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC repository.

^b An aliquot contains sufficient material (volume and concentration) for at least two IVF or several artificial inseminations (based on our procedures). The MMRRC makes no guarantee concerning success of these procedures when performed outside the MMRRC facilities.

^c An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.