Strain Name:
C57BL/6J-Stat1m1Btlr/Mmucd
Stock Number:
011917-UCD
Citation ID:
RRID:MMRRC_011917-UCD
Other Names:
Domino
Major Collection:

Strain Information

Stat1m1Btlr
Name: signal transducer and activator of transcription 1; mutation 1, Bruce Beutler
Synonyms: Domino, Stat1Dom, Dom
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20846
Homologene: 21428
Genetic Alterations
Domino carries a missense mutation.
Genotype Determination
Phenotype
Homozygous: Domino mutants show the same phenotype than STAT1 KO mice: susceptibility to viral and bacteria infections in vivo and in vitro.

Heterozygous: Domino could show an intermediate phenotype for viral infection in vitro, between wild-type mice and homozygous mutants.
Mammalian Phenotype Terms
Allelic Composition: Stat1m1Btlr/Stat1m1Btlr (Genetic Background: C57BL/6J-Stat1m1Btlr )

MeSH Terms
  • Animals
  • Ethylnitrosourea/pharmacology
  • Germ-Line Mutation
  • Herpesviridae Infections/genetics
  • Immunity, Innate/genetics
  • Interferon Type I/genetics
  • Interferon Type I/physiology
  • Macrophages/virology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muromegalovirus/genetics
  • Mutagenesis
  • Point Mutation
  • Rhabdoviridae Infections/etiology
  • Rhabdoviridae Infections/veterinary
  • STAT1 Transcription Factor/genetics
  • STAT1 Transcription Factor/physiology
  • Transcription Factors/genetics
  • Vesicular stomatitis Indiana virus/pathogenicity
Strain Development
Domino germline mutants were identified from an in vivo screen aiming to find new genes of susceptibility to MCMV infection. Domino strain comes from random breedings of F3 germline mutants, which come from the breeding of F1 male and F2 females. F2 females come from F1 male mated with C57BL/6 females. F1 male was generated from a F0 male mated with C57BL/6 females. The F0 founder male was injected ENU.
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
  • Apoptosis
  • Cancer
  • Immunology and Inflammation
  • Models for Human Disease
  • Virology
Donor
Bruce Beutler, M.D., The Scripps Research Institute
Primary Reference

Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, Beutler B. Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406. (Medline PMID: 16688530)

For additional information, please see: Mutagenetix, a catalogue of mutations identified in the Beutler Laboratory at The Scripps Research Institute.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
011917-UCD-EMBRYO Cryo-preserved embryos $1,038.00 / Non-Profit Aliquot Approximate quantity2 : 20-40 embryos / aliquot
011917-UCD-SPERM Cryo-preserved spermatozoa $546.25 / Non-Profit Aliquot Approximate quantity3
011917-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.