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Homozygous: We observed a mouse with a markedly lean body and thoracic kyphosis among the third generation (G3) of C57BL/6J mice carrying mutations induced by ENU. Both male and female homozygotes were highly infertile. Mutant mice had a statistically shortened life span compared with control littermates, with deaths beginning around three months of age. Male and female homozygous spmd mice fed standard rodent chow exhibited lower body weight, body mass index, and body length relative to wild-type littermates. When challenged with a high fat diet (HFD), spmd homozygotes increased it by only 1.3-fold (as opposed to 1.5-fold or 1.8-fold in wild-type mice over a 6-month period indicating elevated resistance to HFD-induced obesity in spmd mice. Glucose tolerance was impaired due to diminished insulin release in homozygous mutant mice.
Heterozygous: Not characterized.
Chen Z, Holland W, Shelton J, Ali A, Zhan X, Tomisato W, Liu C, Li X, Moresco, EMY, and Beutler B. Mutation of mouse Samd4 causes the supermodel phenotype: leanness, myopathy, uncoupled respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A. 2014 May 5.(Medline PMID: 24799716)
Chen Z, Won S, Murray AR, Beutler B. Record for supermodel. MUTAGENETIXTM, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.