Strain Detail Sheet

Strain Name:
C57BL/6J-LynM2Btlr/Mmmh
Stock Number:
038154--TBD-
Citation ID:
RRID:MMRRC_038154--TBD-
Other Names:
Cress
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

LynM2Btlr
Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 2, Bruce Beutler
Synonyms: Cress
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
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Genetic Alterations
ENU-induced T to A transversion at base pair 3,789,908 (v38) on chromosome 4, or base pair 111,788 in the GenBank genomic region NC_000070 for the Lyn gene. The mutation corresponds to residue 1,752 in the mRNA sequence NM_001111096 within exon 13 of 13 total exons and residue 1,689 in the mRNA sequence NM_010747 within exon 13 of 13 total exons. The mutation results in substitution of tyrosine 501 (Tyr501) for a premature stop codon (Tyr501*) in the Lynpp56 protein and a Tyr480* in the Lyn53 protein.

Strain Description

Phenotype

Homozygous: Mice showed showed showed a diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum), a diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded β-galactosidase (rSFV-β-gal), and a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

Heterozygous: Mice showed showed a diminished T-dependent antibody response intermediate between wild-type and homozygous to ovalbumin administered with aluminum hydroxide (OVA/Alum), a intermediate response between wild-type and homozygous T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded β-galactosidase (rSFV-β-gal), and a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Wang K-W, Choi JH, Watthanasurorot A, Murray AR, Beutler B. Record for Cress. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

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Fees

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