Strain Detail Sheet

Strain Name:
C57BL/6J-Ccr7m1Btlr/Mmmh
Stock Number:
038185--TBD-
Citation ID:
RRID:MMRRC_038185--TBD-
Other Names:
lanzhou
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Ccr7m1Btlr
Name: C-C motif chemokine receptor 7; mutation 1, Bruce Beutler
Synonyms: lanzhou
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Ccr7
Name: C-C motif chemokine receptor 7
Synonyms: EBI1, Ebi1h, CD197, Cmkbr7
Type: Gene
Species: Mouse
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12775
HGNC: HGNC:1608
Homologene: 1387
Genome Browser [Click image to go to Jbrowse]



Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced T to A transversion at base pair 99,145,277 (v38) on chromosome 11, or base pair 9,801 in the GenBank genomic region NC_000077 for the Ccr7 gene. The mutation corresponds to residue 897 in the mRNA sequence NM_007719 within exon 3 of 3 total exons. The mutation results in an isoleucine (L) to lysine (K) substitution at position 273 (I273K) in the chemokine (C-C motif) receptor 7 (CCR7) protein.

Strain Description

Phenotype

Homozygous: Mice exhibit increase in the CD4+ to CD8+ T cell ratio in the peripheral blood caused by an increased frequency of CD4+ T cells. Some mice also exhibited a reduced frequency of macrophages in the peripheral blood.

Heterozygous: Mice exhibit a reduced frequency of macrophages in the peripheral blood.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • hematopoietic system
  • immune system
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Zeng M, Murray AR, Beutler B. Record for lanzhou. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.