Strain Detail Sheet

Strain Name:
C57BL/6J-Rac2m1Btlr/Mmmh
Stock Number:
038186--TBD-
Citation ID:
RRID:MMRRC_038186--TBD-
Other Names:
bingo
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Rac2m1Btlr
Name: Rac family small GTPase 2; mutation 1, Bruce Beutler
Synonyms: bingo
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mouse
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
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Genetic Alterations
ENU-induced A to G transition at base pair 78,564,968 (v38) on chromosome 15, or base pair 7,816 in the GenBank genomic region NC_000081 for the Rac2 gene. The mutation corresponds to residue 481 in the mRNA sequence NM_009008 within exon 5 of 7 total exons. The mutation results in a threonine (T) to alanine (A) substitution at position 115 (T115A) in the Rac2 (Ras-related C3 botulinum toxin substrate 2) protein.

Strain Description

Phenotype

Homozygous: Mice exhibit a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

Heterozygous: Mice showed a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygous bingo mice.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Choi JH, Wang K-W, Zeng M, Murray AR, Beutler B. Record for bingo. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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