Strain Detail Sheet

Strain Name:
C57BL/6J-Cd22m4Btlr/Mmmh
Stock Number:
038209--TBD-
Citation ID:
RRID:MMRRC_038209--TBD-
Other Names:
gansu
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Cd22m4Btlr
Name: CD22 antigen; mutation 4, Bruce Beutler
Synonyms: gansu
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Cd22
Name: CD22 antigen
Synonyms: Lyb-8, Lyb8
Type: Gene
Species: Mouse
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
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Genetic Alterations
ENU-induced G to A transition at base pair 30,870,105 (v38) on chromosome 7, or base pair 10,238 in the GenBank genomic region NC_000073 for the Cd22 gene. The mutation corresponds to residue 1,948 in the mRNA sequence NM_001043317 (variant 1) within exon 10 of 16 total exons and to residue 1,823 in the mRNA sequence NM_009845 (variant 2) within exon 8 of 14 total exons. The mutated nucleotide is indicated in red. The mutation results in a valine (V) to methionine (M) substitution at position 529 (V529M) in both isoforms of the CD22 protein.

Strain Description

Phenotype

Homozygous: Mice showed a decreased in the B:T cell ratio caused by a diminished frequency of B cells, a reduced frequency of IgM+ B cells, a decreased percentage of IgD+ B cells, a reduced frequency of B2 cells, an increased frequency of B1a cells, and an increased frequency of B1a cells in B1 cells, all in the peripheral blood.

Heterozygous: No abnormal immune phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Immunology and Inflammation

Strain Origin

Primary Reference

Zeng M, Zhong X, Murray AR, Beutler B. Record for gansu. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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