Homozygous: Mice exhibited a decrease in the B:T cell ratio caused by a reduced frequency of T cells coupled with a greater diminution of B cells, B1 cells, IgM+ B cells, and IgD+ B cells, all in the peripheral blood. Some mice also exhibited an increase in the CD4+ to CD8+ T cell ratio caused by a reduced frequency of CD4+ T cells and na ve CD4 T cells in CD4 T cells coupled with a diminution of the frequency of CD8+ T cells, CD8+ T cells in CD3+ T cells, and na ve CD8 T cells in CD8 T cells, all in the peripheral blood. Some mice exhibited a reduced frequency of natural killer (NK) cells as well as increased frequencies of effector memory CD8 T cells in CD8 T cells, CD11c+ dendritic cells, and macrophages, all in the peripheral blood. Some mice also exhibited a diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide.

Heterozygous: No abnormal phenotype detected.

• Immunology and Inflammation
• Models for Human Disease
• Autosomal recessive T- and NK-cell negative/B-cell positive type of severe combined immunodeficiency [T?B+NK- SCID; OMIM: #600802]

Wang K-W, Choi JH, Murray AR, Beutler B. Record for thistle. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.