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Homozygous: Mice exhibited impaired IgE and IgG1 responses to the cysteine protease papain. Some mice also exhibited an increased viral titer in the liver after exposure to mouse cytomegalovirus (MCMV). Mice exhibited an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection. Some mice also exhibited a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection.
Heterozygous: Mice exhibited impaired IgE and IgG1 responses to the cysteine protease papain. Mice exhibited an increase in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of peripheral CD8+ T cells in CD3 T cells after MCMV infection. Some mice also exhibited a reduced frequency of B1a cells in B1 cells and an increased frequency of B1b cells in B1 cells in the peripheral blood after MCMV infection. Values intermediate between wild-type and homozygous Impaired mice.
SoRelle J, Misawa T, Chen Z, Murray AR, Beutler B. Record for Impaired. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
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