Strain Detail Sheet

Strain Name:
C57BL/6J-Scn8am2Btlr/Mmmh
Stock Number:
038240--TBD-
Citation ID:
RRID:MMRRC_038240--TBD-
Other Names:
dan
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Scn8am2Btlr
Name: sodium channel, voltage-gated, type VIII, alpha; mutation 2, Bruce Beutler
Synonyms: dan
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: nmf2, nur14, C630029C19Rik, seal, med, motor end-plate disease, ataxia 3, nmf335, mnd2, mnd-2, nmf58, NaCh6, NMF335, Nav1.6
Type: Gene
Species: Mouse
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20273
Homologene: 7927
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Additional Resources
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KOMP Phenotyping
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GeneCards
ClinGen
Genetic Alterations
ENU-induced A to T transversion at base pair 101,035,624 (v38) on Chromosome 15, or base pair 165,802 in the GenBank genomic region NC_000081 for the Scn8a

Strain Description

Phenotype

Homozygous: Mice exhibited hindlimb paralysis.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: Scn8am2Btlr/Scn8am2Btlr (Genetic Background: C57BL/6J-Scn8am2Btlr )
  • behavior/neurological
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Neurobiology
  • Cell Biology

Strain Origin

Primary Reference

Weatherly J, Purrington T, Murray AR, Beutler B. Record for dan. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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