Strain Detail Sheet

Strain Name:
C57BL/6J-Scn8am3Btlr/Mmmh
Stock Number:
038248--TBD-
Citation ID:
RRID:MMRRC_038248--TBD-
Other Names:
nymph
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Scn8am3Btlr
Name: sodium channel, voltage-gated, type VIII, alpha; mutation 3, Bruce Beutler
Synonyms: nymph
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mouse
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20273
Homologene: 7927
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Genetic Alterations
ENU-induced A to G transition at base pair 101,035,646 (v38) on chromosome 15, or base pair 165,824 in the GenBank genomic region NC_000081 for the Scn8a gene. The mutation corresponds to residue 4,883 in the mRNA sequence NM_001077499 within exon 26 of 27 total exons. The mutation results in a tyrosine (Y) to cysteine (C) substitution at amino acid 1577 (Y1577C) in the SCN8A protein.

Strain Description

Phenotype

Homozygous: Mice exhibited decreased body weights when compensating for age and sex. These mice also had a mild tremor and an ataxic gait.

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact . Older strains may not have this information.

Research Applications

  • Cell Biology
  • Neurobiology

Strain Origin

Primary Reference

SoRelle J, Chen Z, McAlpine W, Hutchins N,, Murray AR, Beutler B. Record for nymph. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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