Strain Name:
C57BL/6J-MtgxR1076Btlr/Mmmh
Stock Number:
039162-MU
Citation ID:
RRID:MMRRC_039162-MU
Other Names:
R1076 (G1), C57BL/6J-MtgxR1076Btlr
Major Collection:

Strain Information

Ulk2
Name: unc-51 like kinase 2
Synonyms: A830085I22Rik, Unc51.2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 29869
Homologene: 5891
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Slc2a1
Name: solute carrier family 2 (facilitated glucose transporter), member 1
Synonyms: Glut-1, M100200, Glut1, Rgsc200
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20525
Homologene: 68520
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Larp4
Name: La ribonucleoprotein 4
Synonyms: D330037H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207214
VEGA: 15
Homologene: 19173
Nbn
Name: nibrin
Synonyms: Nbs1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27354
HGNC: HGNC:7652
Homologene: 1858
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: 1010001P06Rik, SLC41A1-L2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71699
Homologene: 23052
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: Zfp161, ZF5, b2b1982Clo
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22666
Homologene: 2560
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
Cldn4
Name: claudin 4
Synonyms: Cpetr1, Cpetr
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12740
HGNC: HGNC:2046
Homologene: 1000
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: Hsh2, ALX
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209488
Homologene: 13142
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12990
HGNC: HGNC:2445
Gsap
Name: gamma-secretase activating protein
Synonyms: A530088I07Rik, Pion
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212167
Homologene: 45504
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Ang4
Name: angiogenin, ribonuclease A family, member 4
Synonyms: Rnase5d
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219033
HGNC: HGNC:483
Homologene: 135633
Ankrd50
Name: ankyrin repeat domain 50
Synonyms: E430012K20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99696
Homologene: 129859
Cdh17
Name: cadherin 17
Synonyms: BILL-cadherin, LI-cadherin, HPT-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Apbb1
Name: amyloid beta precursor protein binding family B member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Srp54a
Name: signal recognition particle 54A
Synonyms: 54kDa, 54K subunit of signal recognition particle, Srp54
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24067
VEGA: 12
Homologene: 2362
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, PI3Kgamma, p110gamma, 5830428L06Rik, PI(3)Kgamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639774
Homologene: 106613
Lypd10
Name: Ly6/PLAUR domain containing 10
Synonyms: BC049730
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232972
Elovl2
Name: ELOVL fatty acid elongase 2
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2, Ssc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 54326
Homologene: 23042
Cnn1
Name: calponin 1
Synonyms: calponin h1, CN, CnnI
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12797
VEGA: 9
HGNC: HGNC:2155
Homologene: 995
Dram1
Name: DNA-damage regulated autophagy modulator 1
Synonyms: 1200002N14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71712
Homologene: 41255
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: MMCM2, MMSpi2, D12Rp54, contrapsin, Spi2, RP54, 1300001I07Rik, Spi-2, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,315,938 bp
  • A to T, chromosome 2 at 15,009,472 bp
  • A to G, chromosome 2 at 52,204,892 bp
  • T to C, chromosome 3 at 38,454,922 bp
  • T to C, chromosome 3 at 72,934,098 bp
  • T to C, chromosome 4 at 11,795,581 bp
  • A to T, chromosome 4 at 15,970,719 bp
  • T to A, chromosome 4 at 111,927,219 bp
  • T to G, chromosome 4 at 119,134,448 bp
  • T to A, chromosome 4 at 123,292,908 bp
  • T to C, chromosome 4 at 123,385,598 bp
  • A to G, chromosome 5 at 21,287,694 bp
  • C to T, chromosome 5 at 73,124,673 bp
  • A to T, chromosome 5 at 87,676,383 bp
  • A to G, chromosome 5 at 134,946,337 bp
  • G to A, chromosome 6 at 90,644,160 bp
  • A to G, chromosome 7 at 24,713,742 bp
  • T to G, chromosome 7 at 72,185,867 bp
  • A to T, chromosome 7 at 105,573,855 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • A to T, chromosome 9 at 22,107,869 bp
  • C to A, chromosome 10 at 88,325,384 bp
  • A to G, chromosome 10 at 88,772,459 bp
  • A to T, chromosome 10 at 88,772,543 bp
  • T to C, chromosome 10 at 127,563,797 bp
  • G to A, chromosome 11 at 61,819,309 bp
  • G to A, chromosome 12 at 32,195,714 bp
  • T to C, chromosome 12 at 55,255,528 bp
  • A to G, chromosome 12 at 104,340,994 bp
  • A to G, chromosome 13 at 41,190,107 bp
  • C to T, chromosome 13 at 48,586,810 bp
  • T to A, chromosome 14 at 47,694,638 bp
  • T to C, chromosome 14 at 51,764,302 bp
  • C to T, chromosome 15 at 73,540,733 bp
  • A to G, chromosome 15 at 99,997,430 bp
  • C to A, chromosome 17 at 69,388,502 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1076 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039162-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.