Strain Name:
C57BL/6J-MtgxR3951Btlr/Mmmh
Stock Number:
040828-MU
Citation ID:
RRID:MMRRC_040828-MU
Other Names:
R3951 (G1), C57BL/6J-MtgxR3951Btlr
Major Collection:

Strain Information

Epha4
Name: Eph receptor A4
Synonyms: Cek8, Sek, Tyro1, Hek8, 2900005C20Rik, Sek1, rb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: Cla-1, D5Ertd460e, Hdlq1, Chohd1, Hlb398, SRBI, Srb1, Cd36l1, Chohd1, SR-BI
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: trp2, TRPC2a, mTrp2, Trrp2, TRPC2b, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Skap2
Name: src family associated phosphoprotein 2
Synonyms: Saps, 2610021A10Rik, SKAP-HOM, RA70, mSKAP55R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54353
Homologene: 2919
Ndnf
Name: neuron-derived neurotrophic factor
Synonyms: epidermacan, A930038C07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68169
Homologene: 11593
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, D130071B19Rik, Nirf
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109113
Homologene: 17001
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, 2810406C15Rik, CNAP1, 2810465G24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: Zak, MLTKbeta, B230120H23Rik, MLTKalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65964
Homologene: 32331
Tubb3
Name: tubulin, beta 3 class III
Synonyms: 3200002H15Rik, Tuj1, betaIII-tubulin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22152
Homologene: 68503
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Fkbp8
Name: FK506 binding protein 8
Synonyms: 38kDa, Fkbp38
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14232
HGNC: HGNC:3724
Homologene: 7720
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Gda
Name: guanine deaminase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14544
HGNC: HGNC:4212
Homologene: 3171
Csgalnact1
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Synonyms: 4732435N03Rik, CSGalNAcT-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234356
Homologene: 23099
Hsd17b11
Name: hydroxysteroid (17-beta) dehydrogenase 11
Synonyms: retSDR2, Pan1b, 17beta-HSD11, Dhrs8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114664
Homologene: 69209
Dera
Name: deoxyribose-phosphate aldolase
Synonyms: 2010002D22Rik, 2500002K03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232449
Homologene: 14562
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: jog, PMCA2, wms, Tmy, D6Abb2e, Gena300
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: 4732452O09Rik, Gpig4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320292
Homologene: 14860
Akr1c18
Name: aldo-keto reductase family 1, member C18
Synonyms: 20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105349
HGNC: HGNC:386
Homologene: 128661
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Or9s23
Name: olfactory receptor family 9 subfamily S member 23
Synonyms: MOR208-1, GA_x6K02T2R7CC-81180849-81179878, Olfr1413
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259039
Homologene: 128165
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: D10Ertd690e, NIMP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170728
Homologene: 13105
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269582
Homologene: 11138
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71096
Homologene: 56834
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: C030021G16Rik, Gabrb-2, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66605
Homologene: 45135
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: 3321401G04Rik, 2810407D09Rik, A230020K05Rik, Fam115a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77574
Homologene: 8815
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Spata7
Name: spermatogenesis associated 7
Synonyms: B230306G18Rik, HSD3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104871
Homologene: 10189
Or5al7
Name: olfactory receptor family 5 subfamily AL member 7
Synonyms: Olfr1043, MOR185-7, GA_x6K02T2Q125-47631900-47630956
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258570
Homologene: 88364
Nmur2
Name: neuromedin U receptor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216749
Homologene: 49618
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Lrrc8d
Name: leucine rich repeat containing 8D
Synonyms: 4930525N13Rik, Lrrc5, 2810473G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231549
Homologene: 10004
Or8g2
Name: olfactory receptor family 8 subfamily G member 2
Synonyms: GA_x6K02T2PVTD-33608180-33608971, Olfr973, GA_x6K02T02EEW-227-373, Olfr229, MOR171-14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258606
VEGA: 9
Homologene: 115513
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Gm10283
Name: predicted gene 10283
Synonyms: EG330776
Type: Gene
Species: Mouse
Chromosome: 8
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Ndst-1, Hsst, 1200015G06Rik, b2b2230Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, lysoPAFAT/LPCAT2, Aytl1a, LPCAT2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270084
Homologene: 41201
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328381
Homologene: 19164
Prb1b
Name: proline-rich protein BstNI subfamily 1B
Synonyms: MP5, Prpmp5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381832
Or5w10
Name: olfactory receptor family 5 subfamily W member 10
Synonyms: MOR176-3, GA_x6K02T2Q125-49048592-49047657, Olfr1128
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258346
Vmn2r43
Name: vomeronasal 2, receptor 43
Synonyms: EC2-V2R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381838
Homologene: 113703
Gm527
Name: predicted gene 527
Synonyms: LOC217648
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217648
VEGA: 12
Homologene: 19024
Osgep
Name: O-sialoglycoprotein endopeptidase
Synonyms: PRSMG1, 1500019L24Rik, GCPL-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66246
Homologene: 6395
Hoxb2
Name: homeobox B2
Synonyms: Hox-2.8, Hoxbes2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103889
HGNC: HGNC:5113
Homologene: 37584
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 8,782,901 bp
  • G to A, chromosome 1 at 66,671,722 bp
  • A to T, chromosome 1 at 77,399,716 bp
  • T to A, chromosome 1 at 92,573,789 bp
  • A to G, chromosome 2 at 25,442,637 bp
  • T to C, chromosome 2 at 68,664,403 bp
  • T to G, chromosome 2 at 72,438,300 bp
  • G to T, chromosome 2 at 86,162,618 bp
  • T to C, chromosome 2 at 87,545,065 bp
  • C to T, chromosome 2 at 142,707,359 bp
  • A to T, chromosome 3 at 27,130,120 bp
  • A to G, chromosome 4 at 126,576,379 bp
  • G to A, chromosome 4 at 139,393,094 bp
  • A to T, chromosome 5 at 99,223,050 bp
  • G to A, chromosome 5 at 103,992,937 bp
  • G to T, chromosome 5 at 105,814,276 bp
  • G to T, chromosome 5 at 125,032,256 bp
  • A to C, chromosome 5 at 125,287,411 bp
  • T to C, chromosome 6 at 42,679,059 bp
  • T to C, chromosome 6 at 51,859,984 bp
  • T to C, chromosome 6 at 65,703,141 bp
  • G to A, chromosome 6 at 72,426,558 bp
  • T to A, chromosome 6 at 113,760,831 bp
  • T to C, chromosome 6 at 125,186,784 bp
  • G to A, chromosome 6 at 132,312,694 bp
  • A to G, chromosome 6 at 137,837,120 bp
  • T to A, chromosome 7 at 8,255,320 bp
  • T to C, chromosome 7 at 79,682,069 bp
  • T to A, chromosome 7 at 102,093,574 bp
  • A to T, chromosome 8 at 15,084,556 bp
  • C to T, chromosome 8 at 60,501,364 bp
  • T to C, chromosome 8 at 68,461,262 bp
  • T to A, chromosome 8 at 70,532,661 bp
  • G to T, chromosome 8 at 92,864,903 bp
  • C to A, chromosome 8 at 123,421,264 bp
  • A to T, chromosome 9 at 39,910,725 bp
  • T to A, chromosome 10 at 43,909,897 bp
  • T to C, chromosome 10 at 60,657,326 bp
  • C to T, chromosome 10 at 81,080,629 bp
  • T to C, chromosome 10 at 100,615,296 bp
  • A to G, chromosome 11 at 42,626,881 bp
  • T to C, chromosome 11 at 55,296,382 bp
  • G to C, chromosome 11 at 56,040,225 bp
  • A to G, chromosome 11 at 96,353,175 bp
  • T to A, chromosome 12 at 5,140,660 bp
  • T to G, chromosome 12 at 64,923,502 bp
  • T to C, chromosome 12 at 81,722,521 bp
  • T to A, chromosome 12 at 98,669,473 bp
  • C to T, chromosome 13 at 4,135,285 bp
  • T to G, chromosome 13 at 21,982,128 bp
  • G to C, chromosome 13 at 55,268,454 bp
  • T to G, chromosome 13 at 76,130,219 bp
  • A to G, chromosome 14 at 40,872,546 bp
  • A to G, chromosome 14 at 50,916,875 bp
  • G to A, chromosome 17 at 80,424,181 bp
  • T to C, chromosome 18 at 60,697,139 bp
  • T to C, chromosome 19 at 5,756,001 bp
  • T to C, chromosome 19 at 21,472,445 bp
  • G to A, chromosome 19 at 30,079,861 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3951 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.