Strain Name:
C57BL/6J-MtgxR4094Btlr/Mmmh
Stock Number:
041628-MU
Citation ID:
RRID:MMRRC_041628-MU
Other Names:
R4094 (G1), C57BL/6J-MtgxR4094Btlr
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20349
Homologene: 8247
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Kdm4c
Name: lysine (K)-specific demethylase 4C
Synonyms: 2410141F18Rik, Jmjd2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76804
Homologene: 41004
Syngr3
Name: synaptogyrin 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20974
Homologene: 3101
Dhx35
Name: DEAH-box helicase 35
Synonyms: 1200009D07Rik, Ddx35
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71715
Homologene: 6406
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20527
Homologene: 74302
Ptcd2
Name: pentatricopeptide repeat domain 2
Synonyms: 1190005P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68927
VEGA: 13
Homologene: 11695
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, Sfrs8, 1190005N23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Rbfox2
Name: RNA binding protein, fox-1 homolog (C. elegans) 2
Synonyms: 2810460A15Rik, Fbm2, Fxh, Rbm9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 93686
VEGA: 15
HGNC: HGNC:9906
Homologene: 49375
Vmp1
Name: vacuole membrane protein 1
Synonyms: 3110098I04Rik, Tmem49, Tango5, 4930579A11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75909
Homologene: 23686
Prr12
Name: proline rich 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233210
Homologene: 18957
Cct8
Name: chaperonin containing TCP1 subunit 8
Synonyms: Tcpq, Cctq
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12469
HGNC: HGNC:1623
Homologene: 4802
Atxn2
Name: ataxin 2
Synonyms: ATX2, Sca2, 9630045M23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22722
Homologene: 7604
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-gamma1, Cded, Plc-1, Plcg-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Rab27a
Name: RAB27A, member RAS oncogene family
Synonyms: 2210402C08Rik, 2410003M20Rik, 4933437C11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11891
HGNC: HGNC:9766
Homologene: 3069
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: Etohd4, ZFYVE24
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13998
Homologene: 14209
Erp29
Name: endoplasmic reticulum protein 29
Synonyms: Erp31, Erp28, PDI-Db, 2810446M09Rik, 1200015M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67397
Homologene: 4963
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: Fam160a2, 6530415H11Rik, 4632419K20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74349
Homologene: 75329
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: Efha2, 2900075B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78506
Homologene: 15058
Gna13
Name: guanine nucleotide binding protein, alpha 13
Synonyms: Galpha13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14674
HGNC: HGNC:4381
Homologene: 55976
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: Smsr, 1700010P07Rik, 1110053F04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67630
Homologene: 41670
Foxn3
Name: forkhead box N3
Synonyms: 5430426H20Rik, Ches1l, Ches1, HTLFL1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270118
Homologene: 134147
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Zfp943
Name: zinc finger prtoein 943
Synonyms: 4930432O21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74670
Homologene: 134342
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434218
Homologene: 128238
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Cadm2
Name: cell adhesion molecule 2
Synonyms: Igsf4d, 2900078E11Rik, A830029E02Rik, Necl3, SynCAM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: Aof1, 4632428N09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218214
Homologene: 14695
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: Rit1, COUP-TF interacting protein 2, CTIP2, B630002E05Rik, 9130430L19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 58208
Homologene: 10974
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, 2700017I06Rik, C230040M21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Or5m5
Name: olfactory receptor family 5 subfamily M member 5
Synonyms: Olfr1030, MOR196-2, GA_x6K02T2Q125-47462755-47463693
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258581
Homologene: 64892
Tigd4
Name: tigger transposable element derived 4
Synonyms: C130063O11Rik, Tigd4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 403175
Homologene: 131124
Nccrp1
Name: non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
Synonyms: 1190020J12Rik, LOC233038
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233038
Homologene: 19257
Loxl1
Name: lysyl oxidase-like 1
Synonyms: LOXL
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16949
VEGA: 9
HGNC: HGNC:6665
Homologene: 4074
Mfsd2b
Name: MFSD2 lysolipid transporter B, sphingolipid
Synonyms: Gm1964, major facilitator superfamily domain containing 2B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432628
Homologene: 47753
Lilrb4b
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4B
Synonyms: Lilr4b, Gp49a, gp49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14727
HGNC: HGNC:6608
Homologene: 86756
Or51aa5
Name: olfactory receptor family 51 subfamily AA member 5
Synonyms: MOR15-1, MOR15-4, GA_x6K02T2PBJ9-6236637-6235666, Olfr611
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258722
Homologene: 79675
Gtpbp3
Name: GTP binding protein 3
Synonyms: 2410009F13Rik, Gtpbp3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70359
Homologene: 6600
Rsbn1
Name: rosbin, round spermatid basic protein 1
Synonyms: C230004D03Rik, Rsbp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229675
Homologene: 10154
St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms: Siat8d, PST, PST-1, ST8SiaIV
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20452
Homologene: 4147
Ehf
Name: ets homologous factor
Synonyms: 9030625L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13661
HGNC: HGNC:3246
Homologene: 7301
Cdc25b
Name: cell division cycle 25B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12531
HGNC: HGNC:1726
Homologene: 41451
Cpne4
Name: copine IV
Synonyms: 4933406O10Rik, 3632411M23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74020
HGNC: HGNC:2317
Homologene: 26078
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Or8s10
Name: olfactory receptor family 8 subfamily S member 1
Synonyms: MOR160-2, Olfr282, GA_x6K02T2NBG7-5293798-5292872
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 258449
Homologene: 133621
Amz1
Name: archaelysin family metallopeptidase 1
Synonyms: 6530401C20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231842
Homologene: 18290
Spc25
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2600017H08Rik, 2610205L13Rik, Spbc25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66442
Homologene: 41387
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Gm11133, Pgc-1alpha, A830037N07Rik, Pgc-1alphaa, Pgc1, Pgco1, PPAR Gamma Coactivator-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Pdxk
Name: pyridoxal (pyridoxine, vitamin B6) kinase
Synonyms: 2310036D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216134
HGNC: HGNC:8819
Homologene: 2731
Cym
Name: chymosin
Synonyms: LOC229697, Gm131
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229697
Homologene: 129841
Or8k18
Name: olfactory receptor family 8 subfamily K member 18
Synonyms: MOR187-1, Olfr1049, GA_x6K02T2Q125-47735396-47734470
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259018
Homologene: 77387
Gm3650
Name: predicted gene 3650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042074
Zscan4f
Name: zinc finger and SCAN domain containing 4F
Synonyms: C330039H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665902
Homologene: 85986
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 90,014,425 bp
  • A to T, chromosome 1 at 95,627,686 bp
  • A to G, chromosome 2 at 4,611,032 bp
  • G to A, chromosome 2 at 69,202,631 bp
  • T to C, chromosome 2 at 76,900,516 bp
  • A to G, chromosome 2 at 85,984,218 bp
  • T to C, chromosome 2 at 86,255,330 bp
  • T to C, chromosome 2 at 103,290,750 bp
  • A to G, chromosome 2 at 131,189,117 bp
  • T to A, chromosome 2 at 158,842,356 bp
  • A to G, chromosome 2 at 160,747,841 bp
  • T to C, chromosome 2 at 168,925,935 bp
  • A to G, chromosome 3 at 84,594,640 bp
  • T to A, chromosome 3 at 103,928,658 bp
  • A to G, chromosome 3 at 107,214,266 bp
  • T to A, chromosome 4 at 74,311,678 bp
  • C to T, chromosome 4 at 123,459,269 bp
  • A to G, chromosome 5 at 14,233,690 bp
  • C to A, chromosome 5 at 14,855,645 bp
  • T to C, chromosome 5 at 51,490,064 bp
  • A to G, chromosome 5 at 121,452,282 bp
  • T to C, chromosome 5 at 121,795,048 bp
  • A to G, chromosome 5 at 129,560,741 bp
  • A to T, chromosome 5 at 140,752,166 bp
  • A to T, chromosome 6 at 122,735,568 bp
  • A to T, chromosome 7 at 11,401,258 bp
  • T to C, chromosome 7 at 28,544,226 bp
  • A to G, chromosome 7 at 45,047,947 bp
  • T to A, chromosome 7 at 103,518,037 bp
  • A to G, chromosome 7 at 104,334,588 bp
  • T to C, chromosome 7 at 105,388,218 bp
  • T to G, chromosome 8 at 40,335,888 bp
  • T to C, chromosome 8 at 71,490,631 bp
  • G to A, chromosome 9 at 13,620,153 bp
  • G to A, chromosome 9 at 58,312,456 bp
  • A to C, chromosome 9 at 73,075,544 bp
  • A to G, chromosome 9 at 104,686,535 bp
  • A to C, chromosome 9 at 108,113,870 bp
  • A to T, chromosome 10 at 51,481,410 bp
  • T to C, chromosome 10 at 78,464,810 bp
  • C to A, chromosome 10 at 94,043,434 bp
  • A to G, chromosome 11 at 86,643,580 bp
  • T to A, chromosome 11 at 109,396,416 bp
  • T to A, chromosome 11 at 120,469,033 bp
  • A to G, chromosome 12 at 4,865,241 bp
  • A to T, chromosome 12 at 85,956,602 bp
  • G to T, chromosome 12 at 99,196,441 bp
  • T to A, chromosome 12 at 103,070,249 bp
  • G to T, chromosome 12 at 107,916,835 bp
  • T to C, chromosome 13 at 47,063,020 bp
  • A to G, chromosome 13 at 99,332,449 bp
  • A to G, chromosome 13 at 111,756,162 bp
  • T to C, chromosome 14 at 21,793,045 bp
  • G to A, chromosome 14 at 74,706,349 bp
  • A to T, chromosome 15 at 77,132,725 bp
  • T to C, chromosome 15 at 98,437,682 bp
  • A to T, chromosome 16 at 66,882,797 bp
  • T to G, chromosome 16 at 87,487,628 bp
  • T to A, chromosome 17 at 21,992,982 bp
  • G to A, chromosome 17 at 24,689,843 bp
  • A to T, chromosome 18 at 43,475,126 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4094 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.