Strain Name:
C57BL/6J-MtgxR5111Btlr/Mmmh
Stock Number:
042699-MU
Citation ID:
RRID:MMRRC_042699-MU
Other Names:
R5111 (G1), C57BL/6J-MtgxR5111Btlr
Major Collection:

Strain Information

Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: Btbd11, 6330404E16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: KAT9, 2610507P14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Abhd17c
Name: abhydrolase domain containing 17C
Synonyms: 2210412D01Rik, Fam108c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70178
Homologene: 26429
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, Pps, putative PI-5-phosphatase, PI-5-phosphatase related
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19062
Homologene: 75059
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68925
Homologene: 32269
Nufip2
Name: nuclear FMR1 interacting protein 2
Synonyms: 9530056D24Rik, 1110001M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68564
Homologene: 10808
Mdm2
Name: transformed mouse 3T3 cell double minute 2
Synonyms: 1700007J15Rik, Mdm-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17246
HGNC: HGNC:6973
Homologene: 1793
Palb2
Name: partner and localizer of BRCA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233826
Homologene: 11652
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Nusap1
Name: nucleolar and spindle associated protein 1
Synonyms: NuSAP, 2610201A12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108907
Homologene: 10207
Capns1
Name: calpain, small subunit 1
Synonyms: Capa4, D7Ertd146e, Capn4, Capa-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12336
HGNC: HGNC:1481
Homologene: 1327
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2a, NZF-2b, Nztf2, Nzf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Echdc2
Name: enoyl Coenzyme A hydratase domain containing 2
Synonyms: 2610009M20Rik, 1300017C12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52430
Homologene: 23088
Klrb1c
Name: killer cell lectin-like receptor subfamily B member 1C
Synonyms: Nk-1, CD161, Nk1.1, NK-RP1, NKR-P1, Ly55c, Ly-59, Nk-1.2, Nk1, Ly59, Nkrp1-c, NK-1.1, NKR-P1C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17059
HGNC: HGNC:6373
Homologene: 84369
Rab23
Name: RAB23, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19335
Homologene: 7503
Per1
Name: period circadian clock 1
Synonyms: m-rigui, Hftm, mPer1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Zfand2a
Name: zinc finger, AN1-type domain 2A
Synonyms: Airap
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100494
Homologene: 64373
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: 2010309L07Rik, vp165, IRAP, 4732490P18Rik, gp160
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Tnr
Name: tenascin R
Synonyms: TN-R, J1-tenascin, restrictin, janusin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Liph
Name: lipase, member H
Synonyms: PLA1B, mPA-PLA1, D16Wsu119e, C130037N08Rik, LPDLR, Lpdlr
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Csf3r
Name: colony stimulating factor 3 receptor
Synonyms: Csfgr, G-CSFR, Cd114
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12986
HGNC: HGNC:2439
Homologene: 601
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170826
Homologene: 15776
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Crxos
Name: cone-rod homeobox, opposite strand
Synonyms: Crxos1, Egam1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546024
Homologene: 136482
Zdhhc8
Name: zinc finger, DHHC domain containing 8
Synonyms: E330009O14Rik, Op53c05, D16H22S1738E
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27801
VEGA: 16
Homologene: 8363
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Mterf1a
Name: mitochondrial transcription termination factor 1a
Synonyms: Mterf, Mterf1, 4931431L11Rik, 9230106K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545725
Homologene: 5073
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: A beta, H2-Ab, Ia-2, H-2Ab, Rmcs1, I-Ab, IAb, Ia2, Abeta, I-Abeta
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14961
Homologene: 1603
Hyal2
Name: hyaluronoglucosaminidase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15587
HGNC: HGNC:5321
Homologene: 7776
Btbd3
Name: BTB domain containing 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228662
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13085
Homologene: 69128
Kank3
Name: KN motif and ankyrin repeat domains 3
Synonyms: 0610013D04Rik, Ankrd47, D17Ertd288e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80880
Homologene: 12749
4732440D04Rik
Name: RIKEN cDNA 4732440D04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: Aeg2, CRISP-3, SGP28, CRS3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11572
Homologene: 135665
Ccnjl
Name: cyclin J-like
Synonyms: LOC380694
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380694
Homologene: 11588
Vstm2l
Name: V-set and transmembrane domain containing 2-like
Synonyms: LOC277432
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277432
Homologene: 15414
Ighv6-3
Name: immunoglobulin heavy variable 6-3
Synonyms: Gm16930
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629845
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 6,214,634 bp
  • T to C, chromosome 1 at 33,738,304 bp
  • A to G, chromosome 1 at 66,527,995 bp
  • C to T, chromosome 1 at 159,886,228 bp
  • T to A, chromosome 2 at 119,630,356 bp
  • A to T, chromosome 2 at 119,771,247 bp
  • A to T, chromosome 2 at 121,211,387 bp
  • T to A, chromosome 2 at 138,278,909 bp
  • A to G, chromosome 2 at 157,935,469 bp
  • A to G, chromosome 2 at 181,795,885 bp
  • G to T, chromosome 3 at 87,994,207 bp
  • A to T, chromosome 4 at 108,169,797 bp
  • T to C, chromosome 4 at 126,030,068 bp
  • A to G, chromosome 5 at 3,891,860 bp
  • A to T, chromosome 5 at 90,242,999 bp
  • A to G, chromosome 5 at 139,473,754 bp
  • A to G, chromosome 5 at 142,127,845 bp
  • A to T, chromosome 5 at 151,562,448 bp
  • C to T, chromosome 6 at 128,786,005 bp
  • G to A, chromosome 7 at 15,896,217 bp
  • A to G, chromosome 7 at 27,036,621 bp
  • A to G, chromosome 7 at 30,192,519 bp
  • A to T, chromosome 7 at 84,151,438 bp
  • A to T, chromosome 7 at 122,117,305 bp
  • A to G, chromosome 8 at 14,932,408 bp
  • A to G, chromosome 8 at 111,044,912 bp
  • C to T, chromosome 9 at 105,709,474 bp
  • T to C, chromosome 9 at 107,571,111 bp
  • T to C, chromosome 9 at 109,436,728 bp
  • T to C, chromosome 10 at 85,654,567 bp
  • A to T, chromosome 10 at 117,691,221 bp
  • A to G, chromosome 11 at 43,556,717 bp
  • A to T, chromosome 11 at 69,100,786 bp
  • C to T, chromosome 11 at 75,647,264 bp
  • T to A, chromosome 11 at 77,691,843 bp
  • A to T, chromosome 11 at 85,077,331 bp
  • T to C, chromosome 11 at 99,986,552 bp
  • A to T, chromosome 12 at 114,391,774 bp
  • A to G, chromosome 13 at 107,728,635 bp
  • A to C, chromosome 14 at 65,560,236 bp
  • G to T, chromosome 16 at 18,226,748 bp
  • G to A, chromosome 16 at 21,984,070 bp
  • A to C, chromosome 16 at 90,752,017 bp
  • A to G, chromosome 17 at 17,578,610 bp
  • A to T, chromosome 17 at 18,326,064 bp
  • A to G, chromosome 17 at 33,818,181 bp
  • T to A, chromosome 17 at 34,267,482 bp
  • T to C, chromosome 17 at 40,225,804 bp
  • C to A, chromosome 18 at 34,651,689 bp
  • A to T, chromosome 18 at 37,091,505 bp
  • A to T, chromosome 18 at 61,310,487 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5111 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042699-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.