Strain Name:
C57BL/6J-MtgxR5241Btlr/Mmmh
Stock Number:
042812-MU
Citation ID:
RRID:MMRRC_042812-MU
Other Names:
R5241 (G1), C57BL/6J-MtgxR5241Btlr
Major Collection:

Strain Information

Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Gatad2a
Name: GATA zinc finger domain containing 2A
Synonyms: 1110066C11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234366
Homologene: 9766
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Cot, Tpl2, c-COT, Tpl-2, Cot/Tpl2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22643
Homologene: 137226
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Runx2
Name: runt related transcription factor 2
Synonyms: AML3, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1, PEBP2 alpha A, PEBP2aA, Osf2, Cbfa1, Pebpa2a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Prss14, Epithin, MT-SP1, matriptase, Tmprss14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19143
Homologene: 7906
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76965
VEGA: 14
Homologene: 14174
Atl1
Name: atlastin GTPase 1
Synonyms: AD-FSP, SPG3, FSP1, Spg3a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73991
VEGA: 12
Homologene: 9302
Bhmt
Name: betaine-homocysteine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12116
HGNC: HGNC:1047
Homologene: 1295
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: MCCalpha, MCCA, 1810045E08Rik, 2310058B18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: Clc2, ClC-2, nmf240
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Afp
Name: alpha fetoprotein
Synonyms: alpha-foetoprotein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11576
HGNC: HGNC:317
Homologene: 36278
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Misshapen/NIKs-related kinase, MINK, Ysk2, Map4k6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, Myhs-f2, Myhs-f, Myhsf2, A530084A17Rik, MYHC-IIX, myosin heavy chain 2X, IId, IId/x
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Sdr9c7
Name: 4short chain dehydrogenase/reductase family 9C, member 7
Synonyms: SDR-O, Rdhs, 1810054F20Rik, Sdro, Rdh20
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70061
Homologene: 23618
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Tas2r123
Name: taste receptor, type 2, member 123
Synonyms: T2R23, Tas2r23, STC 9-2, mGR23, mt2r55
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353167
Homologene: 45450
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Glis3
Name: GLIS family zinc finger 3
Synonyms: E330013K21Rik, 4833409N03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226075
Homologene: 34989
Tmem144
Name: transmembrane protein 144
Synonyms: 1110057I03Rik, 5730537D05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70652
Homologene: 41250
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72160
Homologene: 12798
Dnase2a
Name: deoxyribonuclease II alpha
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13423
HGNC: HGNC:2960
Homologene: 68179
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: C230075L19Rik, Zyg11bl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227693
Homologene: 4621
Or4p19
Name: olfactory receptor family 4 subfamily P member 19
Synonyms: GA_x6K02T2Q125-49900552-49899623, MOR225-1, Olfr1180
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258920
Homologene: 74240
Gsdmc3
Name: gasdermin C3
Synonyms: 9930109F21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 270328
HGNC: HGNC:7151
Homologene: 69487
Or6k8-ps1
Name: olfactory receptor family 6 subfamily K member 8, pseudogene 1
Synonyms: GA_x6K02T2P20D-21006310-21006124, GA_x6K02T2P20D-21002372-21001425, MOR105-3, Olfr421, Olfr422-ps1, Olfr421-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258715
Msantd1
Name: Myb/SANT-like DNA-binding domain containing 1
Synonyms: LOC231132, A930005I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403174
Homologene: 45807
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: RIP14, FXR, HRR1, Fxr, Rxrip14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Or51f1e
Name: olfactory receptor family 51 subfamily F member 1E
Synonyms: GA_x6K02T2PBJ9-5809085-5810035, MOR14-4, Olfr585
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259091
Homologene: 133721
Bsnd
Name: barttin CLCNK type accessory beta subunit
Synonyms: Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140475
Homologene: 14291
Spr-ps1
Name: sepiapterin reductase pseudogene 1
Synonyms: Sprp, EG665089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 665089
Tmem252
Name: transmembrane protein 252
Synonyms: E030010A14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226040
VEGA: 19
Homologene: 17717
Gm10784
Name: predicted pseudogene 10784
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100040099
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,111,790 bp
  • G to A, chromosome 1 at 127,491,552 bp
  • T to A, chromosome 1 at 174,152,101 bp
  • A to C, chromosome 2 at 30,104,970 bp
  • C to T, chromosome 2 at 67,482,360 bp
  • T to C, chromosome 2 at 88,412,098 bp
  • G to A, chromosome 2 at 126,383,726 bp
  • T to A, chromosome 3 at 35,974,196 bp
  • A to T, chromosome 3 at 79,814,124 bp
  • A to G, chromosome 4 at 106,487,985 bp
  • A to G, chromosome 5 at 34,921,469 bp
  • A to G, chromosome 5 at 90,501,614 bp
  • T to C, chromosome 6 at 85,155,913 bp
  • T to C, chromosome 6 at 132,847,218 bp
  • A to T, chromosome 7 at 28,085,199 bp
  • T to C, chromosome 7 at 103,098,317 bp
  • G to A, chromosome 8 at 69,918,017 bp
  • A to G, chromosome 8 at 84,909,268 bp
  • A to T, chromosome 8 at 117,035,118 bp
  • G to T, chromosome 9 at 31,100,418 bp
  • A to T, chromosome 10 at 76,433,617 bp
  • A to G, chromosome 10 at 80,312,234 bp
  • A to G, chromosome 10 at 89,483,489 bp
  • T to G, chromosome 10 at 127,909,790 bp
  • T to A, chromosome 11 at 67,204,449 bp
  • C to T, chromosome 11 at 70,599,090 bp
  • C to A, chromosome 11 at 120,271,403 bp
  • T to C, chromosome 12 at 69,959,113 bp
  • T to A, chromosome 13 at 49,945,093 bp
  • A to T, chromosome 13 at 81,488,929 bp
  • T to A, chromosome 13 at 93,624,808 bp
  • A to G, chromosome 14 at 108,913,012 bp
  • A to G, chromosome 15 at 8,079,216 bp
  • C to T, chromosome 15 at 63,824,894 bp
  • A to G, chromosome 15 at 63,864,146 bp
  • A to G, chromosome 16 at 20,709,703 bp
  • T to C, chromosome 16 at 35,429,775 bp
  • G to T, chromosome 16 at 36,931,936 bp
  • T to C, chromosome 17 at 30,984,092 bp
  • C to T, chromosome 17 at 33,382,236 bp
  • G to T, chromosome 17 at 44,639,777 bp
  • T to C, chromosome 18 at 4,340,750 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • T to C, chromosome 19 at 24,674,127 bp
  • G to T, chromosome 19 at 28,350,023 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5241 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042812-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.