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Availability & Fees Order this Strain
The original founder population or 112 male and female outbred Hsd:ICR were split into 8 closed lines (with no sib-mating), which were bred under selection for high voluntary activity. At S51/52, line 6 was found to be recessive for Myh4minimsc.
Fourteen mice homozygous for Myh4minimsc were bred randomly for two generations to establish 20 non-interbreeding lineages, which were randomly sib-mated for 4 generations (F4). Beginning in generation F5, the mice were tested for voluntary running behavior. All potential breeding individuals were individually housed with a running wheel of 0.7-m circumference. Revolutions were summed for the 5th and 6th night of a 7-day exposure. In each generation, the top 1-3 male and female mice from each lineage were selected as breeders for the next generation. Due to genetic incompatibilities, all lineages but one went extinct by generation F12; all remaining mice are descendants of this original pairing. At generation F30, the wheel testing was terminated due to minimal residual genetic variation. At the time of donation to the MMRRC, the animals were at F38. Mean distance run over the final two nights by the last set of breeders was 11 km, with a maximum pair of 14 km. Full pedigree information is available for all mice.
Swallow JG, Carter PA, Garland T Jr. Artificial selection for increasedwheel-running behavior in house mice. Behav Genet. 1998 May;28(3):227-37. (Medline PMID: 9670598)
Garland T Jr, Morgan MT, Swallow JG, Rhodes JS, Girard I, Belter JG, CarterPA. Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels. Evolution. 2002 Jun;56(6):1267-75. (Medline PMID: 12144025)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
The donor or their institution limits the distribution to non-profit institutions only.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.