Strain Name:
C57BL/6J-MtgxR5861Btlr/Mmmh
Stock Number:
044073-MU
Citation ID:
RRID:MMRRC_044073-MU
Other Names:
R5861 (G1)
Major Collection:

Strain Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, Myhc-b, B-MHC, beta-MHC, betaMHC, MyHC-I, Myhcb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: 1200004O12Rik, 5730456G07Rik, Hbp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Rara
Name: retinoic acid receptor, alpha
Synonyms: RAR alpha 1, RARalpha1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19401
HGNC: HGNC:9864
Homologene: 20262
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Crhbp
Name: corticotropin releasing hormone binding protein
Synonyms: CRH-BP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12919
VEGA: 13
HGNC: HGNC:2356
Homologene: 1418
Taf11
Name: TATA-box binding protein associated factor 11
Synonyms: PRO214, TAF2I, TAFII28, 1110038O14Rik, 28kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68776
Homologene: 55918
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: 2900011L11Rik, Abcc5a, Abcc5b, Mrp5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Arsg
Name: arylsulfatase G
Synonyms: 6330406P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74008
Homologene: 8978
Olfm3
Name: olfactomedin 3
Synonyms: optimedin, B230206G02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229759
Homologene: 17103
Rps5
Name: ribosomal protein S5
Synonyms: S5 ribosomal protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20103
Homologene: 783
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: Ccdc128, Klraq1, 1110018J12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73825
Homologene: 44811
Zfp979
Name: zinc finger protein 979
Synonyms: Ssm1, 2610305D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 112422
Homologene: 133076
Sigirr
Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Synonyms: Tir8, Sigirr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 24058
Homologene: 36399
Rexo2
Name: RNA exonuclease 2
Synonyms: Rex2, Sfn, Smfn, 1810038D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104444
VEGA: 9
Homologene: 6447
Nipsnap3b
Name: nipsnap homolog 3B
Synonyms: 2700063N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66536
Homologene: 75044
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Mapk15
Name: mitogen-activated protein kinase 15
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 332110
Homologene: 16371
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69439
Homologene: 72545
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: NRH: quinone oxidoreductase, Ox-2, Ox2, Nmor2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 407812
Nadsyn1
Name: NAD synthetase 1
Synonyms: 9130012B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78914
Homologene: 6098
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, 2700012E02Rik, Cog2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Tmed6
Name: transmembrane p24 trafficking protein 6
Synonyms: 1810015P03Rik, 1810018I24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66269
Homologene: 11938
Pld5
Name: phospholipase D family member 5
Synonyms: B230365F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319455
Homologene: 16081
Cyp2j6
Name: cytochrome P450, family 2, subfamily j, polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13110
HGNC: HGNC:2634
Homologene: 68091
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Or4e1
Name: olfactory receptor family 4 subfamily E member 1
Synonyms: Olfr1508, GA_x6K02T2RJGY-520647-521579, MOR244-2, MOR244-4, MOR10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57270
HGNC: HGNC:8296
Homologene: 10737
Myf5
Name: myogenic factor 5
Synonyms: B130010J22Rik, Myf-5, bHLHc2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17877
VEGA: 10
HGNC: HGNC:7565
Homologene: 4085
Uevld
Name: UEV and lactate/malate dehyrogenase domains
Synonyms: 8430408E05Rik, Attp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54122
Homologene: 69251
Mfsd10
Name: major facilitator superfamily domain containing 10
Synonyms: 0610009O03Rik, Tetran
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68294
Homologene: 871
Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
Synonyms: 6OST3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50787
VEGA: 14
Homologene: 89201
Trim5
Name: tripartite motif-containing 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667823
Homologene: 75345
Fkbpl
Name: FK506 binding protein-like
Synonyms: WAF-1/CIP1 stabilizing protein 39, DIR1, NG7, WISp39, Ppiase-X
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56299
Homologene: 10529
Spam1
Name: sperm adhesion molecule 1
Synonyms: Ph-20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20690
Homologene: 7547
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99334
Homologene: 17586
Ercc2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms: Mhdarco15, XPD, Ercc-2, RCO015
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13871
HGNC: HGNC:3434
Homologene: 344
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Or7a37
Name: olfactory receptor family 7 subfamily A member 37
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2, Olfr1353
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259044
Homologene: 131345
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Nt5dc3
Name: 5'-nucleotidase domain containing 3
Synonyms: C630002B14Rik, Gnn
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103466
VEGA: 10
Homologene: 9571
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Papolb
Name: poly (A) polymerase beta (testis specific)
Synonyms: Papt, Plap-ps, TPAP, Papola-ps
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56522
Homologene: 121622
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70859
Homologene: 52823
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54201
Homologene: 69231
Taar7a
Name: trace amine-associated receptor 7A
Synonyms: LOC215856, Taar7a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215856
Homologene: 110833
Il5
Name: interleukin 5
Synonyms: Il-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16191
HGNC: HGNC:6016
Homologene: 679
Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
Synonyms: 1700016F14Rik, mDj6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56691
Homologene: 23184
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 4930471A21Rik, 5330407H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: Olfr1141, MOR177-10, GA_x6K02T2Q125-49257818-49256883
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Kif1c
Name: kinesin family member 1C
Synonyms: N-3 kinsin, B430105J22Rik, D11Bwg1349e, Orch3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16562
HGNC: HGNC:6317
Homologene: 4821
Man1b1
Name: mannosidase, alpha, class 1B, member 1
Synonyms: E430019H13Rik, MANA-ER, LOC227619
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227619
HGNC: HGNC:6823
Homologene: 5230
Gpr150
Name: G protein-coupled receptor 150
Synonyms: C030001A19Rik, PGR11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238725
Homologene: 18457
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245867
Homologene: 10099
Gm28042
Name: predicted gene, 28042
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102238433
Gm13035
Name: predicted gene 13035
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 102637947
Homologene: 137330
Gm28455
Name: predicted gene 28455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101056047
Homologene: 140592
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 127,387,392 bp
  • T to G, chromosome 1 at 176,090,005 bp
  • A to G, chromosome 2 at 25,348,054 bp
  • G to T, chromosome 2 at 52,742,104 bp
  • A to T, chromosome 2 at 87,753,578 bp
  • T to C, chromosome 2 at 120,034,635 bp
  • G to T, chromosome 2 at 121,164,037 bp
  • C to A, chromosome 2 at 153,399,390 bp
  • C to A, chromosome 2 at 181,842,475 bp
  • T to A, chromosome 3 at 64,556,033 bp
  • G to C, chromosome 3 at 95,736,597 bp
  • T to A, chromosome 3 at 115,122,403 bp
  • A to G, chromosome 4 at 53,021,177 bp
  • A to T, chromosome 4 at 86,791,352 bp
  • A to G, chromosome 4 at 96,545,803 bp
  • G to T, chromosome 4 at 143,571,240 bp
  • A to G, chromosome 4 at 146,073,289 bp
  • G to A, chromosome 4 at 147,613,509 bp
  • T to C, chromosome 5 at 34,634,244 bp
  • T to C, chromosome 5 at 142,529,237 bp
  • T to C, chromosome 5 at 143,263,340 bp
  • A to G, chromosome 6 at 24,796,571 bp
  • G to A, chromosome 6 at 54,290,374 bp
  • A to G, chromosome 6 at 88,223,106 bp
  • T to C, chromosome 6 at 91,741,033 bp
  • T to A, chromosome 7 at 12,925,574 bp
  • G to C, chromosome 7 at 19,394,141 bp
  • T to A, chromosome 7 at 39,498,579 bp
  • A to T, chromosome 7 at 46,926,356 bp
  • A to G, chromosome 7 at 96,843,217 bp
  • A to G, chromosome 7 at 100,444,475 bp
  • C to A, chromosome 7 at 102,009,287 bp
  • G to T, chromosome 7 at 104,279,519 bp
  • A to C, chromosome 7 at 104,279,521 bp
  • A to G, chromosome 7 at 140,812,139 bp
  • G to A, chromosome 7 at 141,091,379 bp
  • A to C, chromosome 7 at 143,811,227 bp
  • C to T, chromosome 8 at 77,310,764 bp
  • G to T, chromosome 8 at 107,064,154 bp
  • T to C, chromosome 8 at 124,537,878 bp
  • A to T, chromosome 9 at 48,475,181 bp
  • T to C, chromosome 10 at 23,992,439 bp
  • A to T, chromosome 10 at 78,969,931 bp
  • A to T, chromosome 10 at 86,815,874 bp
  • A to T, chromosome 10 at 107,484,208 bp
  • C to T, chromosome 10 at 119,929,970 bp
  • G to A, chromosome 11 at 53,723,916 bp
  • C to T, chromosome 11 at 61,737,044 bp
  • T to C, chromosome 11 at 70,703,795 bp
  • T to C, chromosome 11 at 85,311,848 bp
  • T to A, chromosome 11 at 98,968,161 bp
  • T to A, chromosome 11 at 109,563,188 bp
  • A to G, chromosome 11 at 119,473,377 bp
  • C to T, chromosome 12 at 85,040,886 bp
  • A to T, chromosome 13 at 33,972,430 bp
  • A to G, chromosome 13 at 63,298,812 bp
  • A to T, chromosome 13 at 76,056,073 bp
  • G to A, chromosome 13 at 95,443,825 bp
  • T to C, chromosome 14 at 52,463,496 bp
  • A to G, chromosome 14 at 54,988,890 bp
  • T to C, chromosome 14 at 75,107,366 bp
  • A to G, chromosome 14 at 119,138,853 bp
  • T to A, chromosome 15 at 74,606,607 bp
  • C to A, chromosome 15 at 75,996,359 bp
  • G to T, chromosome 16 at 20,399,894 bp
  • T to C, chromosome 17 at 27,901,670 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • T to C, chromosome 17 at 88,582,509 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5861 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044073-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.