Strain Name:
C57BL/6J-MtgxR6252Btlr/Mmmh
Stock Number:
044369-MU
Citation ID:
RRID:MMRRC_044369-MU
Other Names:
R6252 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: PC-1, PC1, polycystin-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, ne, b2b1562Clo, 6030440P17Rik, my
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: ANT-1, 2610031L17Rik, 1190003A07Rik, U5-102K
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, Yod, 3010027A04Rik, 2410104C19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12331
Homologene: 74572
Zmat3
Name: zinc finger matrin type 3
Synonyms: Wig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22401
Homologene: 32545
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229681
Homologene: 14910
Pwp1
Name: PWP1 homolog, endonuclein
Synonyms: 2610205J09Rik, 2310058A11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103136
Homologene: 5129
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Zfp981
Name: zinc finger protein 981
Synonyms: Gm13247
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041433
Homologene: 133076
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 360216
Homologene: 9728
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83691
Homologene: 12857
Slc44a3
Name: solute carrier family 44, member 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213603
Homologene: 64830
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30044
VEGA: 14
Homologene: 69152
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22062
Homologene: 3960
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 9430004C13Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Stc2
Name: stanniocalcin 2
Synonyms: mustc2, Stc2l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20856
Homologene: 2753
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: ABC16, Lith1, PFIC2, sister of P-glycoprotein, Bsep, PGY4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Esyt1
Name: extended synaptotagmin-like protein 1
Synonyms: vp115, Mbc2, Fam62a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23943
VEGA: 10
Homologene: 40794
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Npas3
Name: neuronal PAS domain protein 3
Synonyms: bHLHe12, 4930423H22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Elapor2
Name: endosome-lysosome associated apoptosis and autophagy regulator family member 2
Synonyms: 9330182L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231014
Homologene: 27396
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAPP-A, IGFBP-4ase, 8430414N03Rik, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: equatorin, 4930579C15Rik, Afaf, 1700028B15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Rsph10b
Name: radial spoke head 10 homolog B (Chlamydomonas)
Synonyms: 4930526H21Rik, Rsph10b2
Type: Gene
Species: Mouse
Chromosome: 5
Homologene: 18321
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Id-1, E030024J03Rik, IDPc, Idh-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Col8a1
Name: collagen, type VIII, alpha 1
Synonyms: Col8a-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12837
HGNC: HGNC:2215
Homologene: 22423
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Kctd15
Name: potassium channel tetramerisation domain containing 15
Synonyms: MGC25497
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233107
Homologene: 11450
Pdlim2
Name: PDZ and LIM domain 2
Synonyms: mystique, SLIM, 4732462F18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213019
Homologene: 11006
AW146154
Name: expressed sequence AW146154
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101835
Homologene: 134516
Cavin2
Name: caveolae associated 2
Synonyms: Sdpr, cavin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20324
Homologene: 3422
Zfp772
Name: zinc finger protein 772
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232855
Homologene: 128539
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Or10w3
Name: olfactory receptor family 10 subfamily W member 3
Synonyms: MOR266-3, Olfr1493, GA_x6K02T2RE5P-4059239-4060188
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258735
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 17,749,507 bp
  • A to G, chromosome 1 at 51,289,669 bp
  • T to G, chromosome 1 at 65,168,531 bp
  • T to C, chromosome 2 at 69,291,961 bp
  • T to C, chromosome 2 at 120,906,895 bp
  • C to T, chromosome 2 at 181,647,363 bp
  • A to G, chromosome 3 at 32,341,621 bp
  • A to T, chromosome 3 at 53,572,448 bp
  • T to C, chromosome 3 at 104,919,503 bp
  • C to T, chromosome 3 at 116,787,229 bp
  • T to A, chromosome 3 at 121,513,737 bp
  • A to G, chromosome 4 at 65,189,412 bp
  • A to T, chromosome 4 at 94,907,769 bp
  • A to G, chromosome 4 at 122,872,400 bp
  • T to G, chromosome 4 at 146,537,513 bp
  • C to A, chromosome 4 at 154,064,397 bp
  • A to T, chromosome 5 at 6,769,478 bp
  • T to C, chromosome 5 at 9,410,693 bp
  • T to A, chromosome 5 at 21,621,501 bp
  • T to A, chromosome 5 at 143,937,121 bp
  • A to G, chromosome 6 at 48,906,081 bp
  • A to G, chromosome 6 at 140,007,603 bp
  • G to T, chromosome 7 at 7,204,019 bp
  • A to G, chromosome 7 at 34,641,923 bp
  • G to A, chromosome 7 at 41,481,387 bp
  • A to G, chromosome 7 at 132,983,904 bp
  • T to C, chromosome 8 at 122,893,822 bp
  • T to C, chromosome 10 at 82,283,754 bp
  • T to C, chromosome 10 at 85,874,509 bp
  • T to C, chromosome 10 at 128,511,902 bp
  • T to A, chromosome 11 at 31,360,346 bp
  • A to G, chromosome 12 at 54,068,890 bp
  • G to A, chromosome 12 at 71,988,949 bp
  • C to A, chromosome 12 at 75,969,436 bp
  • T to C, chromosome 13 at 14,272,079 bp
  • C to T, chromosome 13 at 89,691,220 bp
  • C to T, chromosome 14 at 34,594,831 bp
  • G to T, chromosome 14 at 70,167,688 bp
  • A to G, chromosome 16 at 57,627,005 bp
  • T to C, chromosome 17 at 24,581,226 bp
  • T to A, chromosome 17 at 34,042,212 bp
  • T to C, chromosome 18 at 37,821,530 bp
  • T to C, chromosome 18 at 77,985,167 bp
  • A to T, chromosome 19 at 13,727,055 bp
  • T to C, chromosome 19 at 46,271,556 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6252 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044369-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.