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Hu Y, Xie Y, Wang Y, Chen X, Smith DE. Development and characterization of anovel mouse line humanized for the intestinal peptide transporter PEPT1. MolPharm. 2014 Oct 6;11(10):3737-46. doi: 10.1021/mp500497p. Epub 2014 Sep 2. PubMedPMID: 25148225; PubMed Central (Medline PMCID: PMC4186676)
Hu Y, Smith DE. In Silico Prediction of the Absorption and Disposition ofCefadroxil in Humans using an Intestinal Permeability Method Scaled fromHumanized PepT1 Mice. Drug Metab Dispos. 2019 Mar;47(3):173-183. doi:10.1124/dmd.118.084236. Epub 2018 Dec 28. (Medline PMID: 30593545)
Hu Y, Smith DE. Species differences in the pharmacokinetics of cefadroxil asdetermined in wildtype and humanized PepT1 mice. Biochem Pharmacol. 2016 May1;107:81-90. doi: 10.1016/j.bcp.2016.03.008. Epub 2016 Mar 12. (Medline PMID: 26979860)
Epling D, Hu Y, Smith DE. Evaluating the intestinal and oral absorption of theprodrug valacyclovir in wildtype and huPepT1 transgenic mice. Biochem Pharmacol. 2018 Sep;155:1-7. doi: 10.1016/j.bcp.2018.06.010. Epub 2018 Jun 21. (Medline PMID: 29935147)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
N8 (C57BL/6NCrl), F10
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.