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Xiao C, Liu N, Jacobson KA, Gavrilova O, Reitman ML. Physiology and effects ofnucleosides in mice lacking all four adenosine receptors. PLoS Biol. 2019 Mar1;17(3):e3000161. doi: 10.1371/journal.pbio.3000161. eCollection 2019 Mar. (Medline PMID: 30822301)
Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J,Schnermann J. Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A. 2001 Aug14;98(17):9983-8. (Medline PMID: 11504952)
Chen JF, Huang Z, Ma J, Zhu J, Moratalla R, Standaert D, Moskowitz MA, FinkJS, Schwarzschild MA. A(2A) adenosine receptor deficiency attenuates brain injuryinduced by transient focal ischemia in mice. J Neurosci. 1999 Nov1;19(21):9192-200. (Medline PMID: 10531422)
Hua X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL. Enhanced mastcell activation in mice deficient in the A2b adenosine receptor. J Exp Med. 2007 Jan 22;204(1):117-28. Epub 2007 Jan 2. Erratum in: J Exp Med. 2007 Apr16;204(4):963. (Medline PMID: 17200408)
Salvatore CA, Tilley SL, Latour AM, Fletcher DS, Koller BH, Jacobson MA.Disruption of the A(3) adenosine receptor gene in mice and its effect onstimulated inflammatory cells. J Biol Chem. 2000 Feb 11;275(6):4429-34. (Medline PMID: 10660615)
Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.
The donor or their institution limits the distribution to non-profit institutions only.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.