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Jenuth JP, Peterson AC, Fu K, Shoubridge EA. Random genetic drift in thefemale germline explains the rapid segregation of mammalian mitochondrial DNA.Nat Genet. 1996 Oct;14(2):146-51. (Medline PMID: 8841183)
Battersby BJ, Loredo-Osti JC, Shoubridge EA. Nuclear genetic control ofmitochondrial DNA segregation. Nat Genet. 2003 Feb;33(2):183-6. Epub 2003 Jan 21.(Medline PMID: 12539044)
Bacman SR, Williams SL, Moraes CT. Intra- and inter-molecular recombination ofmitochondrial DNA after in vivo induction of multiple double-strand breaks.Nucleic Acids Res. 2009 Jul;37(13):4218-26. doi: 10.1093/nar/gkp348. Epub 2009May 12. (Medline PMID: 19435881)
Bacman SR, Williams SL, Hernandez D, Moraes CT. Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiplecleavage-site' model. Gene Ther. 2007 Sep;14(18):1309-18. Epub 2007 Jun 28.(Medline PMID: 17597792)
Battersby BJ, Redpath ME, Shoubridge EA. Mitochondrial DNA segregation inhematopoietic lineages does not depend on MHC presentation of mitochondriallyencoded peptides. Hum Mol Genet. 2005 Sep 1;14(17):2587-94. Epub 2005 Jul 27.(Medline PMID: 16049030)
Bacman SR, Williams SL, Garcia S, Moraes CT. Organ-specific shifts in mtDNAheteroplasmy following systemic delivery of a mitochondria-targeted restrictionendonuclease. Gene Ther. 2010 Jun;17(6):713-20. doi: 10.1038/gt.2010.25. Epub2010 Mar 11. (Medline PMID: 20220783)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.