Strain Detail Sheet

Strain Name:
B6;129P2-Lrp6Gt(EX187)Byg/Mmucd
Stock Number:
030661-UCD
Citation ID:
RRID:MMRRC_030661-UCD
Other Names:
LRP6, B6.129P2-Lrp6Gt(Ex187)Byg/Mmcd
Major Collection:
BayGenomics

Strain Information

Gene Details

Lrp6Gt(Ex187)Byg
Name: low density lipoprotein receptor-related protein 6; gene trap Ex187, BayGenomics
Synonyms: Lrp6lacZ, Lrp6betageo, lrp6-, Lrp6Gt(pGT1.8TM)187Wcs
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Gene Trap
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, Cd, ska26, skax26
Type: Gene
Species: Mouse
Chromosome: 6
Alteration at locus: Gene Trap
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Genome Browser [Click image to go to Jbrowse]



Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genotype Determination

Genotyping Protocol

ES Cell Line
CGR8 derived from 129P2/OlaHsd

Strain Description

Phenotype
Homozygous: Perinatally lethal, Skeletal defects, Limb defects, microophthalmia, Urogenital defects, Neural defects

Heterozygous: Same as wild-type.
Mammalian Phenotype Terms
Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg (Genetic Background: involves: 129P2/OlaHsd )
Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg (Genetic Background: involves: 129P2/OlaHsd * C57BL/6 )
Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+ (Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N )
Allelic Composition: Lrp6Cd/Lrp6Gt(Ex187)Byg (Genetic Background: involves: 129P2/OlaHsd * A )
Allelic Composition: Lrp6rs/Lrp6Gt(Ex187)Byg (Genetic Background: involves: 129P2/OlaHsd * BALB/c )
Allelic Composition: Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg (Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL )
MeSH Terms
  • Animals
  • Cell Line
  • Databases, Nucleic Acid
  • Embryo, Mammalian/cytology
  • Genomics
  • Internet
  • Mice/genetics
  • Mice, Knockout
  • Mutagenesis, Insertional
  • Mutation
  • Stem Cells/cytology
  • User-Computer Interface
Suggested Control Mice
Wild-type littermates

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.

Research Applications

  • Cell Biology
  • Developmental Biology
  • Internal/Organ
  • Models for Human Disease
  • Neurobiology
  • Research Tools
  • Sensorineural

Strain Origin

Donor
William C. Skarnes, Ph.D., Wellcome Trust Sanger Institute.
Primary Reference
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81. (Medline PMID: 12520002)

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@ucdavis.edu

Breeding

MMRRC Breeding System
Backcross followed by sib-mating
Breeding Scheme(s)
  • Wild-type (C57BL/6) female x Heterozygous male or reciprocal mating
  • Wild-type female x Heterozygous male littermate or reciprocal mating
  • Homozygous female x Homozygous male littermate
Generation
N4

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Undetermined Undetermined
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.