• Introduction to the MMRRC

• Background

• Organization

• Contact Information

• MMRRC MTAs

• How to Link to Us

• Strain Detail Sheets

• Catalog Search Form

• Request Form

General Information about the MMRRC

Welcome to the Mutant Mouse Regional Resource Centers (MMRRC) Web site.

The MMRRC consists of three mouse facilities and an information coordinating center functioning as a single, multi-site repository for mouse lines with interesting phenotypes but low demand.

The MMRRC is supported by the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH, DHHS). Our purpose is to ensure the continued availability of scientifically valuable, genetically engineered mice and to distribute these mice to qualified researchers studying human and animal biology and disease. A national network of regional breeding and distribution facilities serves as NIH's premier repository of spontaneous and induced mutant mouse lines.

The MMRRC facilities cryopreserve and distribute mouse strains and mouse ES cell lines with potential value in the research of human disease and biology. Strains of mice are maintained in a cryopreserved state unless demand warrants that a live colony be established. These strains and cell lines are available for distribution to qualified researchers. Live mice are supplied from a production colony, from a colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. At their option, a MMRRC facility may also offer cryopreserved material for resuscitation at the recipient scientist's institution.

Benefits to you ...

As a requesting investigator:

• Access to unique models not commercially available
  
• Specific Pathogen Free health status mice
  
• Genetic Quality Control

As a donating investigator:

• Fulfills your NIH obligation to share biomedical research resources (if applicable)
  
• Frees up animal housing resources
  
• Reduces per diem costs
  
• A cryopreserved archive of the line is created
  
• Eliminates the shipment of mice to multiple requesting investigators
  
• If MMRRC funded, you pay only the cost of shipping mice/material to the MMRRC
  
• If Donor funded, you may negotiate Fee-for-service with the MMRRC

In addition, the MMRRC member facilities develop new technologies to improve the handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.