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May 28, 2013
When expressed in mice, high levels of Neuregulin 1 (Nrg1) lead to behavioral deficits and hypofunction of glutamatergic and GABAergic pathways similar to that found in human patients with schizophrenia. Don-Yin Min, et al. found that these effects are diminished when Nrg1 levels are returned to normal.
The MMRRC has related mouse models.
May 9, 2013
Evidence that that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.
Full publiceation here.
The MMRRC has a related ES cell line.
April 22, 2013
Researchers at UT Southwestern Medical Center have identified a specific gene, Meis1 that regulates the heart’s ability to regenerate after injuries. The original article can be found in Nature.
The MMRRC has a GENSAT mouse containing multiple copies of a modified BAC in which EGFP reporter gene is inserted immediately upstream of the Meis1 coding sequence of the targeted gene.
Welcome to the Mutant Mouse Regional Resource Centers (MMRRC) Web site.
The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. We are a national network of breeding and distribution facilities plus an information coordinating center serving together as NIH's premier repository of spontaneous and induced mutant mouse and cell lines. The MMRRC is supported by the National Center for Research Resources at the National Institutes of Health.
Strains of mice are maintained in a cryopreserved state unless demand warrants that a live colony be established. Live mice are supplied from a production colony, from a colony recovered from cryopreservation, or via micro-injection of a cell line into host blastocysts. At its option, an MMRRC facility may offer cryopreserved material for resuscitation at the recipient scientist's institution. The MMRRC charges fees to partially cover repository costs; please see our Fees page for details.
The MMRRC is a collaborative effort, funded by grants from the NIH