Strain Name:
C57BL/6J-MtgxR6123Btlr/Mmmh
Stock Number:
044270-MU
Citation ID:
RRID:MMRRC_044270-MU
Other Names:
R6123 (G1)
Major Collection:

Strain Information

Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
Synonyms: CRD-BP, IMP-1, Crdbp, Zbp1, D030026A21Rik, D11Moh45, D11Moh40e, IMP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140486
Homologene: 4772
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20650
Homologene: 4911
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: 2410041A17Rik, Bach, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Jrk
Name: jerky
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16469
HGNC: HGNC:6199
Homologene: 2762
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Fam168a
Name: family with sequence similarity 168, member A
Synonyms: 2610030B18Rik, B930006L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319604
Homologene: 18702
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Rnpc3
Name: RNA-binding region (RNP1, RRM) containing 3
Synonyms: C030014B17Rik, 2810441O16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67225
Homologene: 9746
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: Mt-CK, mi-CK, UbCKmit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12716
Homologene: 69058
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Ankrd34b
Name: ankyrin repeat domain 34B
Synonyms: 6430502M16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218440
Homologene: 18450
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: Galpha15, G[a]15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Slc16a1
Name: solute carrier family 16 (monocarboxylic acid transporters), member 1
Synonyms: MCT1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20501
Homologene: 20662
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grm, D5Ucla3, grt, Tango13b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Tubgcp2
Name: tubulin, gamma complex component 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74237
Homologene: 55980
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100317
Homologene: 11764
Thumpd1
Name: THUMP domain containing 1
Synonyms: 6330575P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233802
Homologene: 5878
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208263
Homologene: 9208
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, OATP-D, 5830414C08Rik, Anr1, Slc21a11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
Cyp2j6
Name: cytochrome P450, family 2, subfamily j, polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13110
HGNC: HGNC:2634
Homologene: 68091
Spdye4a
Name: speedy/RINGO cell cycle regulator family, member E4A
Synonyms: 4930445A17Rik, speedy/ringo, speedy B, 4930451F05Rik, Spdyb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74673
Homologene: 134531
P4ha1
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Synonyms: P4ha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18451
HGNC: HGNC:8546
Homologene: 30998
Tnfsf15
Name: tumor necrosis factor (ligand) superfamily, member 15
Synonyms: VEGI, TL1A, TL1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 326623
Homologene: 3755
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: 1110061H03Rik, SRRP129, CASP11, SIP1, 2610510E10Rik, Sfrs2ip, Srsf2ip
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49J, Ly49i2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Btnl10
Name: butyrophilin-like 10
Synonyms: BUTR-1, Butr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192194
Homologene: 138184
Potegl
Name: POTE ankyrin domain family, member G like
Synonyms: 4931423N10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70981
Homologene: 86765
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Pcyox1
Name: prenylcysteine oxidase 1
Synonyms: 1200015P13Rik, PCL1, Pcly
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66881
Homologene: 9458
Clba1
Name: clathrin binding box of aftiphilin containing 1
Synonyms: Flj20080, C130001I08Rik, BC022687
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217887
VEGA: 12
Homologene: 17077
Gm6665
Name: predicted gene 6665
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 626327
VEGA: 18
E430025E21Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 15
Spata31f1e
Name: spermatogenesis associated 31 subfamily F member 1E
Synonyms: Gm12394
Type: Gene
Species: Mouse
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 128,169,036 bp
  • C to T, chromosome 1 at 140,362,980 bp
  • A to G, chromosome 1 at 156,007,205 bp
  • T to C, chromosome 2 at 23,230,122 bp
  • C to G, chromosome 2 at 121,363,579 bp
  • T to A, chromosome 2 at 140,168,389 bp
  • A to T, chromosome 2 at 180,683,967 bp
  • T to A, chromosome 2 at 181,991,227 bp
  • T to C, chromosome 3 at 73,049,762 bp
  • A to G, chromosome 3 at 90,413,554 bp
  • A to G, chromosome 3 at 104,653,194 bp
  • C to T, chromosome 3 at 109,664,365 bp
  • A to T, chromosome 3 at 113,609,056 bp
  • A to G, chromosome 4 at 42,793,065 bp
  • A to G, chromosome 4 at 59,737,565 bp
  • T to C, chromosome 4 at 63,744,925 bp
  • A to T, chromosome 4 at 96,518,029 bp
  • A to G, chromosome 4 at 126,869,386 bp
  • A to T, chromosome 4 at 143,812,764 bp
  • A to G, chromosome 4 at 152,199,945 bp
  • C to A, chromosome 5 at 21,305,597 bp
  • C to T, chromosome 5 at 112,308,218 bp
  • T to C, chromosome 5 at 143,225,718 bp
  • A to G, chromosome 6 at 86,388,928 bp
  • T to C, chromosome 6 at 130,279,376 bp
  • C to T, chromosome 7 at 74,318,506 bp
  • A to G, chromosome 7 at 100,824,150 bp
  • A to T, chromosome 7 at 119,717,009 bp
  • T to C, chromosome 7 at 140,007,597 bp
  • A to T, chromosome 8 at 3,437,091 bp
  • G to A, chromosome 8 at 106,981,225 bp
  • A to G, chromosome 9 at 66,497,250 bp
  • A to T, chromosome 10 at 59,350,527 bp
  • A to G, chromosome 10 at 81,509,344 bp
  • C to A, chromosome 11 at 58,920,304 bp
  • T to C, chromosome 11 at 69,518,359 bp
  • A to G, chromosome 11 at 95,975,296 bp
  • T to C, chromosome 11 at 119,411,513 bp
  • T to C, chromosome 12 at 75,087,591 bp
  • T to C, chromosome 12 at 112,810,910 bp
  • A to T, chromosome 12 at 113,597,693 bp
  • C to T, chromosome 13 at 68,590,218 bp
  • A to G, chromosome 13 at 92,439,076 bp
  • A to G, chromosome 15 at 59,335,110 bp
  • A to G, chromosome 15 at 74,706,680 bp
  • A to G, chromosome 15 at 96,420,454 bp
  • A to G, chromosome 18 at 31,819,884 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6123 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044270-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.