Strain Name:
C57BL/6J-MtgxR6251Btlr/Mmmh
Stock Number:
044368-MU
Citation ID:
RRID:MMRRC_044368-MU
Other Names:
R6251 (G1)
Major Collection:

Strain Information

Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72515
VEGA: 17
Homologene: 38810
Rap1a
Name: RAS-related protein 1a
Synonyms: Krev-1, Rap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109905
HGNC: HGNC:9855
Homologene: 2162
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Stk39
Name: serine/threonine kinase 39
Synonyms: SPAK, DCHT, RF005, Rnl5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53416
Homologene: 22739
Rnf114
Name: ring finger protein 114
Synonyms: 1110008J21Rik, Znf228, Zfp313
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81018
Homologene: 10265
Cyb5r3
Name: cytochrome b5 reductase 3
Synonyms: Dia1, 2500002N19Rik, Dia-1, 0610016L08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109754
HGNC: HGNC:2873
Homologene: 47921
Dynlt2b
Name: dynein light chain Tctex-type 2B
Synonyms: 0610012D17Rik, 2410011K15Rik, Tctex1d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66061
Homologene: 41625
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Cul5
Name: cullin 5
Synonyms: VACM-1, C330021I08Rik, 4921514I20Rik, C030032G03Rik, 8430423K24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Nectin3
Name: nectin cell adhesion molecule 3
Synonyms: Pvrl3, 2610301B19Rik, nectin-3, 4921513D19Rik, 3000002N23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 58998
Homologene: 9162
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Spink6
Name: serine peptidase inhibitor, Kazal type 6
Synonyms: EG433180
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433180
VEGA: 18
Ms4a6d
Name: membrane-spanning 4-domains, subfamily A, member 6D
Synonyms: Ms4a11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68774
Homologene: 130755
Notch1
Name: notch 1
Synonyms: 9930111A19Rik, lin-12, N1, Motch A, Mis6, Tan1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Extl3
Name: exostosin-like glycosyltransferase 3
Synonyms: 2900009G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54616
VEGA: 14
HGNC: HGNC:3518
Homologene: 1103
Kcnj14
Name: potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms: IRK4, A930026G01Rik, Kir2.4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211480
HGNC: HGNC:6260
Homologene: 27086
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, Mekk5, 7420452D20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Casq1
Name: calsequestrin 1
Synonyms: CSQ1, sCSQ, CSQ-1, CSQ
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12372
HGNC: HGNC:1512
Homologene: 20329
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
3100002H09Rik
Name: RIKEN cDNA 3100002H09 gene
Type: Gene
Species: Mouse
Chromosome: 4
Gfra3
Name: glial cell line derived neurotrophic factor family receptor alpha 3
Synonyms: GFR alpha-3, GFRalpha3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14587
VEGA: 18
HGNC: HGNC:4245
Homologene: 1146
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Daglb
Name: diacylglycerol lipase, beta
Synonyms: E330036I19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231871
Homologene: 34715
Arl6
Name: ADP-ribosylation factor-like 6
Synonyms: 1110018H24Rik, BBS3, 2210411E14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56297
Homologene: 12960
Spopfm1
Name: speckle-type BTB/POZ protein family member 1
Synonyms: Gm4778
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212727
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 4933432P15Rik, 2610010G17Rik, 1810044B20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71302
Homologene: 36349
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Or1e23
Name: olfactory receptor family 1 subfamily E member 23
Synonyms: MOR135-14, MOR135-31_p, Olfr382, GA_x6K02T2P1NL-3676608-3675670
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258435
Homologene: 17252
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Shn3, E030045D18Rik, Krc, 2900056N03Rik, Schnurri-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Tcte1
Name: t-complex-associated testis expressed 1
Synonyms: Tcte-1, D17Sil1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21645
VEGA: 17
Homologene: 8434
Or4a67
Name: olfactory receptor family 4 subfamily A member 67
Synonyms: MOR225-12, Olfr1200, GA_x6K02T2Q125-50243231-50242221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257887
Homologene: 123770
Car15
Name: carbonic anhydrase 15
Synonyms: Cals2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80733
Homologene: 113791
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Agmo
Name: alkylglycerol monooxygenase
Synonyms: Tmem195, A530016O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319660
Homologene: 45620
Trim63
Name: tripartite motif-containing 63
Synonyms: MuRF1, Rnf28
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433766
Homologene: 41878
Pigz
Name: phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms: F630022B06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239827
Homologene: 130742
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: MOR162-6, GA_x6K02T2PVTD-31705144-31706073, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13854
Homologene: 32172
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209760
Homologene: 36424
Mtarc1
Name: mitochondrial amidoxime reducing component 1
Synonyms: Marc1, 1300013F15Rik, Mosc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66112
Homologene: 129604
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Tcstv2a
Name: 2 cell stage variable group member 2A
Synonyms: clone L4 variable group of 2-cell-stage gene family, AF067061, clone L8 variable group of 2-cell-stage gene family
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 236546
Dazap2
Name: DAZ associated protein 2
Synonyms: gt6-12, Gcap28, Brbp, Prtb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23994
VEGA: 15
HGNC: HGNC:2684
Homologene: 8038
Ciart
Name: circadian associated repressor of transcription
Synonyms: Gm129, LOC229599
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229599
Homologene: 79670
Or8g18
Name: olfactory receptor family 8 subfamily G member 18
Synonyms: MOR171-32P, Olfr144, MOR171-41P, MOR171-32P, GA_x6K02T2PVTD-32935684-32934749, K4, Olfr1537, Olfr1537-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257959
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 106,875,065 bp
  • C to T, chromosome 1 at 121,434,540 bp
  • T to A, chromosome 1 at 172,216,840 bp
  • G to A, chromosome 1 at 184,795,451 bp
  • C to A, chromosome 2 at 26,474,170 bp
  • A to T, chromosome 2 at 68,307,039 bp
  • T to C, chromosome 2 at 88,768,288 bp
  • T to C, chromosome 2 at 167,514,729 bp
  • A to T, chromosome 3 at 59,179,107 bp
  • G to T, chromosome 3 at 94,265,901 bp
  • G to A, chromosome 3 at 95,881,011 bp
  • A to T, chromosome 3 at 105,731,995 bp
  • A to T, chromosome 3 at 122,275,256 bp
  • A to G, chromosome 4 at 32,748,590 bp
  • C to A, chromosome 4 at 120,094,940 bp
  • A to G, chromosome 4 at 124,610,652 bp
  • A to T, chromosome 4 at 134,323,226 bp
  • T to C, chromosome 5 at 37,300,499 bp
  • G to A, chromosome 5 at 77,348,294 bp
  • T to A, chromosome 5 at 143,489,934 bp
  • C to A, chromosome 5 at 144,198,576 bp
  • G to T, chromosome 7 at 5,095,926 bp
  • G to T, chromosome 7 at 5,095,936 bp
  • T to A, chromosome 7 at 45,818,016 bp
  • T to C, chromosome 7 at 118,561,038 bp
  • CCTTCTTCT to CCTTCT, chromosome 7 at 139,638,900 bp
  • G to GGGATTGC, chromosome 9 at 38,026,537 bp
  • TGTTT to TGTTTGCAGTTT, chromosome 9 at 38,026,545 bp
  • GTTT to GTTTGCTTTTT, chromosome 9 at 38,026,546 bp
  • TT to TTGCTGTGT, chromosome 9 at 38,026,548 bp
  • T to A, chromosome 9 at 39,238,218 bp
  • A to T, chromosome 9 at 53,646,794 bp
  • T to C, chromosome 9 at 105,654,048 bp
  • T to A, chromosome 10 at 20,138,260 bp
  • C to T, chromosome 10 at 77,989,565 bp
  • G to A, chromosome 11 at 31,055,559 bp
  • A to T, chromosome 11 at 43,235,746 bp
  • A to G, chromosome 11 at 73,516,708 bp
  • A to G, chromosome 12 at 37,252,539 bp
  • G to A, chromosome 12 at 71,988,949 bp
  • G to T, chromosome 12 at 109,593,649 bp
  • T to C, chromosome 13 at 120,263,371 bp
  • T to C, chromosome 14 at 65,076,926 bp
  • T to C, chromosome 15 at 12,160,591 bp
  • T to C, chromosome 15 at 80,336,682 bp
  • T to C, chromosome 15 at 83,154,716 bp
  • T to G, chromosome 15 at 100,616,983 bp
  • A to T, chromosome 16 at 17,837,363 bp
  • T to C, chromosome 16 at 31,945,606 bp
  • T to A, chromosome 16 at 32,426,909 bp
  • A to T, chromosome 16 at 46,395,150 bp
  • T to C, chromosome 16 at 59,618,806 bp
  • A to T, chromosome 17 at 45,535,159 bp
  • G to A, chromosome 17 at 71,650,053 bp
  • TGCGC to TGC, chromosome 18 at 34,695,811 bp
  • A to T, chromosome 18 at 39,357,827 bp
  • T to C, chromosome 18 at 44,074,431 bp
  • A to T, chromosome 19 at 11,587,140 bp
  • T to C, chromosome Y at 921,693 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044368-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.