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A transgene was designed with the human doublecortin (DCX) promoter/enhancer regions upstream of a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). This transgene was microinjected into C57BL/6J blastocysts. Transgenic mice from a single founder line were bred to C57BL/6J mice. These DCX-CreERT2 transgenic mice were subsequently maintained by breeding hemizygous mice with C57BL/6J inbred mice for many generations prior to arrival at the MMRRC.
A sample from this MMRRC strain was analyzed using the Mouse Universal Genotyping Array (MUGA) and MMRRC computational tools were used to assess the genetic background. A summary of the data can be found here.
Colony Surveillance Program and Current Health Reports
The availability level for this product has not been determined.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.