Phenotype Homozygous phenotype: The mutant mice
show progressive hypopigmentation of the fur (grey), with intra- and
inter-hair variegation. The blood cholesterol level is decreased by 75
percent as compared to wild-type values. The mice are sensitive to mouse
cytomegalovirus (MCMV) infections. The killing function of cytotoxic T
cells (CTL) is impaired.
Heterozygous phenotype: The heterozygous mice appear to be wild-type for the phenotypes tested by donor.
Mammalian Phenotype Terms:(provided by MGI)Extend all MPTs assigned by genotype
increased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:146454)
over 90% of mice die within 30 hours of injection with tunicamycin (an endoplasmic reticulum stressor) compared to under 10% for controls
in adults, the coat is of a homogeneous color and made of hair with a white base and a grey/brown tip (MGI Ref ID J:123123)
Founder genetic background: C57BL/6J
Strain genetic background: C57BL/6J
Strain Development: The woodrat mutation is recessive. It was
first isolated as a homozygous G3 male. This original mouse was bred to
C57BL/6 females, and the second generation was backcrossed to the mutant
founder. The woodrat homozygous mutant females have low fertility, thus
the stock is currently maintained as homozygous male bred with
Suggested Control Mice:
Immunology and Inflammation
Bruce Beutler, M.D., The Scripps Research Institute
Brandl K; Rutschmann S; Li X; Du X; Xiao N; Schnabl B; Brenner DA; Beutler B, Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response., Proc Natl Acad Sci U S A 2009 Mar 3;106(9):3300-5
(Medline PMID: 19202076)
For additional information see: Mutagenetix, a catalog of mutations identified in the Beutler Laboratory at The Scripps Research Institute.
Health Status Report
Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email email@example.com.
Order Request Information
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Conditions of Distribution:
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU).
A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded
to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping
costs are in addition to the basic distribution/resuscitation
fees. Information on shipping costs and any additional charges will be provided
by the supplying MMRRC facility.
Click button to Request this one strain.
(Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item #
Fee/unit (US $)
Litter recovered from cryo-archive
Recovered litter1; additional fees for any special requests.
Approximate quantity3: 20-40 embryos / aliquot
The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
An aliquot contains a sufficient number of embryos (in one or more
vials and based on the transfer success rate of the MMRRC facility) to
transfer to at least two recipients. The MMRRC makes no guarantee concerning
embryo transfer success experienced in the recipient investigator's laboratory.
Neither gender nor genotype ratios are guaranteed.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the "Request this Strain" button above). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.
The MMRRC is a collaborative effort, funded by grants from the