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Homozygous: There is abnormal heart morphology detected. There is abnormal immune system physiology detected, homeostasis/metabolism phenotype is detected. Zeitgeist mice have a reduced lifespan and exhibit a spontaneous, progressive and rapidly appearing wasting disease with death occurring 2-3 days after symptoms first appear. Additionally, the numbers of erythropoietic progenitors expressing Ter119 are very high in zeitgeist mice, which may be a consequence of anemia. Some of the mice exhibit internal bleeding. Zeitgeist mice appear similar to their littermates at weaning, but develop progressive cardiomyopathy that is fatal by 7 wk of age. Further studies indicate that these mice die of heart failure as a result of myocardial necrosis, fibrosis, and impairment of myocardial contractility. Electron microscopic examination of cardiomyocytes from homozygous zeitgeist mice found that there was disorganization of the Z-band pattern and shortening of I bands. Mitochondrial morphology was also affected, with deterioration and dysfunction observed.
Heterozygous: Not characterized.
Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. Lethal Mitochondrial Cardiomyopathy in a Hypomorphic Med30 Mouse Mutant is Ameliorated by Ketogenic Diet. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19678-82. (Medline PMID: 22106289).
Krebs P, Moresco EY, Murray A, Beutler B. Record for zeitgeist. MUTAGENETIXTM, B. Beutler and colleagues, The Scripps Research Institute, La Jolla, CA.
Colony Surveillance Program and Current Health Reports
Heterozygous female x Heterozygous male
Wild-type female x Heterozygous male littermate or reciprocal
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.