Strain Name:
C57BL/6J-MtgxR2425Btlr/Mmmh
Stock Number:
040387-MU
Citation ID:
RRID:MMRRC_040387-MU
Other Names:
R2425 (G1), C57BL/6J-MtgxR2425Btlr
Major Collection:

Strain Information

Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Upf1
Name: UPF1 RNA helicase and ATPase
Synonyms: PNORF-1, B430202H16Rik, Rent1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Draxin
Name: dorsal inhibitory axon guidance protein
Synonyms: Neucrin, 2610109H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70433
Homologene: 19233
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Rad23b
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: mHR23B, 0610007D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19359
HGNC: HGNC:9813
Homologene: 37704
Pdxdc1
Name: pyridoxal-dependent decarboxylase domain containing 1
Synonyms: 2210010A19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94184
Homologene: 22858
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Il3
Name: interleukin 3
Synonyms: Il-3, PSF, MCGF, HCGF, BPA, Csfmu
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16187
HGNC: HGNC:6011
Homologene: 49243
Kcne1
Name: potassium voltage-gated channel, Isk-related subfamily, member 1
Synonyms: MinK, Isk, nmf190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16509
VEGA: 16
HGNC: HGNC:6240
Homologene: 185
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Ddx39a
Name: DEAD box helicase 39a
Synonyms: 2610307C23Rik, BAT1, Ddx39
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68278
Homologene: 68487
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Shld2
Name: shieldin complex subunit 2
Synonyms: 3110001K24Rik, Fam35a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75698
VEGA: 14
Homologene: 56840
Rb1
Name: RB transcriptional corepressor 1
Synonyms: pRb, Rb, Rb-1, retinoblastoma 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 3110031A07Rik, 2410140K03Rik, D5Ertd591e, A630018G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83704
Homologene: 5429
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Elane
Name: elastase, neutrophil expressed
Synonyms: NE, F430011M15Rik, Ela2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50701
VEGA: 10
HGNC: HGNC:3309
Homologene: 20455
Pramel1
Name: PRAME like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83491
Homologene: 87078
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Astn1
Name: astrotactin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Gas7
Name: growth arrest specific 7
Synonyms: Gas7-cb, B230343A10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14457
HGNC: HGNC:4169
Homologene: 69015
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, C330021K24Rik, Gababrbp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Gjd4
Name: gap junction protein, delta 4
Synonyms: connexin 39, Cx39, 9430022F06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225152
VEGA: 18
Homologene: 17692
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67909
Homologene: 12210
Bnc1
Name: basonuclin zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33651220-33650288, MOR224-2, Olfr975
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217219
Homologene: 19144
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107141
Homologene: 137231
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217356
Homologene: 45126
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Abcc10
Name: ATP-binding cassette, sub-family C member 10
Synonyms: Mrp7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Gpr161
Name: G protein-coupled receptor 161
Synonyms: LOC240888, vl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240888
Homologene: 17824
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270201
Homologene: 14805
Rbm12b1
Name: RNA binding motif protein 12 B1
Synonyms: 3000004N20Rik, Rbm12b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72397
Homologene: 28658
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: Gm5807, CN725425
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Amacr
Name: alpha-methylacyl-CoA racemase
Synonyms: 2-arylpropionyl-CoA epimerase, Macr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17117
VEGA: 15
HGNC: HGNC:451
Homologene: 7410
Cd44
Name: CD44 antigen
Synonyms: Ly-24, Pgp-1, HERMES
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Or8k21
Name: olfactory receptor family 8 subfamily K member 21
Synonyms: GA_x6K02T2Q125-47793414-47792471, MOR187-4, Olfr1053-ps1, Olfr1053
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257974
Homologene: 74197
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Dnajb14
Name: DnaJ heat shock protein family (Hsp40) member B14
Synonyms: 5730496F10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70604
Homologene: 57015
Zfp935
Name: zinc finger protein 935
Synonyms: 8430426H19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71508
VEGA: 13
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224617
Homologene: 27469
Or2t48
Name: olfactory receptor family 2 subfamily T member 48
Synonyms: GA_x6K02T2NKPP-895420-896349, MOR275-1, Olfr330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258879
Homologene: 133015
Abhd6
Name: abhydrolase domain containing 6
Synonyms: 0610041D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66082
VEGA: 14
Homologene: 23246
Dhrs9
Name: dehydrogenase/reductase 9
Synonyms: C730025I08Rik, Rdh15, dehydrogenase/reductase (SDR family) member 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241452
Homologene: 26079
Gm11295
Name: predicted gene 11295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 665726
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 135,963,102 bp
  • T to G, chromosome 1 at 158,579,666 bp
  • T to A, chromosome 1 at 165,310,623 bp
  • T to A, chromosome 1 at 188,537,804 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • A to G, chromosome 2 at 69,392,964 bp
  • A to G, chromosome 2 at 86,314,395 bp
  • T to A, chromosome 2 at 102,861,586 bp
  • C to A, chromosome 2 at 110,862,843 bp
  • C to G, chromosome 2 at 117,289,450 bp
  • A to G, chromosome 2 at 146,315,064 bp
  • T to C, chromosome 3 at 90,394,110 bp
  • T to G, chromosome 3 at 137,892,905 bp
  • T to A, chromosome 4 at 12,146,443 bp
  • C to T, chromosome 4 at 45,051,642 bp
  • T to A, chromosome 4 at 55,385,438 bp
  • T to C, chromosome 4 at 62,312,365 bp
  • T to G, chromosome 4 at 143,398,466 bp
  • T to A, chromosome 4 at 148,112,756 bp
  • A to G, chromosome 5 at 25,220,081 bp
  • C to T, chromosome 5 at 37,141,805 bp
  • G to T, chromosome 5 at 137,315,597 bp
  • T to C, chromosome 5 at 143,715,839 bp
  • C to A, chromosome 7 at 81,969,031 bp
  • T to C, chromosome 7 at 120,359,810 bp
  • C to T, chromosome 8 at 16,199,843 bp
  • C to T, chromosome 8 at 70,338,460 bp
  • A to G, chromosome 8 at 83,719,606 bp
  • C to T, chromosome 8 at 119,734,281 bp
  • T to A, chromosome 8 at 122,893,163 bp
  • T to C, chromosome 9 at 39,949,841 bp
  • T to C, chromosome 9 at 79,678,366 bp
  • T to C, chromosome 9 at 110,455,491 bp
  • C to T, chromosome 10 at 79,887,776 bp
  • A to T, chromosome 11 at 54,265,549 bp
  • A to G, chromosome 11 at 58,529,311 bp
  • G to A, chromosome 11 at 67,643,295 bp
  • A to C, chromosome 11 at 102,438,361 bp
  • A to G, chromosome 11 at 117,792,569 bp
  • A to G, chromosome 13 at 22,283,060 bp
  • G to T, chromosome 13 at 62,455,108 bp
  • T to A, chromosome 14 at 8,049,857 bp
  • A to G, chromosome 14 at 34,268,689 bp
  • T to C, chromosome 14 at 55,778,017 bp
  • A to G, chromosome 14 at 73,298,172 bp
  • C to A, chromosome 15 at 7,887,359 bp
  • A to G, chromosome 15 at 8,351,482 bp
  • A to G, chromosome 15 at 10,983,368 bp
  • A to C, chromosome 15 at 91,245,855 bp
  • A to T, chromosome 16 at 13,879,508 bp
  • A to G, chromosome 16 at 92,348,758 bp
  • A to T, chromosome 17 at 24,186,008 bp
  • A to G, chromosome 17 at 46,310,157 bp
  • G to T, chromosome 18 at 9,280,811 bp
  • T to A, chromosome 19 at 30,131,790 bp
  • T to C, chromosome 19 at 40,089,848 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2425 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040387-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.