Strain Name:
C57BL/6J-MtgxR4090Btlr/Mmmh
Stock Number:
040983-MU
Citation ID:
RRID:MMRRC_040983-MU
Other Names:
R4090 (G1), C57BL/6J-MtgxR4090Btlr
Major Collection:

Strain Information

Cd36
Name: CD36 molecule
Synonyms: FAT, fatty acid translocase, Scarb3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245945
Homologene: 36932
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106021
Homologene: 4237
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Exoc6
Name: exocyst complex component 6
Synonyms: msec15, 4833405E05Rik, Sec15, Sec15l1, hbd
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Wdr26
Name: WD repeat domain 26
Synonyms: 1600024A01Rik, Gid7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226757
Homologene: 11857
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226442
Homologene: 8270
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Gja8
Name: gap junction protein, alpha 8
Synonyms: Cnx50, connexin 50, alpha 8 connexin, Cx50, Aey5, Lop10, dcm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Hsd17b13
Name: hydroxysteroid (17-beta) dehydrogenase 13
Synonyms: Pan1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243168
Homologene: 71549
Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Synonyms: Lfc, GEF-H1, LFP40, GEFH1, P40, Lbcl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272347
Homologene: 12358
Ppme1
Name: protein phosphatase methylesterase 1
Synonyms: 1110069N17Rik, 2700017M01Rik, PME-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72590
Homologene: 6099
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Igkc
Name: immunoglobulin kappa constant
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16071
HGNC: HGNC:5716
Slurp1
Name: secreted Ly6/Plaur domain containing 1
Synonyms: ARS component B, 1110021N19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57277
Homologene: 10710
Mlxipl
Name: MLX interacting protein-like
Synonyms: WS-bHLH, ChREBP, Wbscr14, bHLHd14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380660
Homologene: 11587
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: GA_x6K02T2P1NL-3932085-3931147, MOR135-6, Olfr389
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Ksr1
Name: kinase suppressor of ras 1
Synonyms: D11Bhm183e, B-KSR1, D11Bhm184e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215243
Homologene: 11885
Or7g17
Name: olfactory receptor family 7 subfamily G member 17
Synonyms: GA_x6K02T2PVTD-12599710-12600648, MOR147-1, Olfr829
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259070
HGNC: HGNC:8466
Homologene: 138324
Sypl2
Name: synaptophysin like 2
Synonyms: Mg29
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17306
Homologene: 7421
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-1, MOR259-13, Olfr1519, Olfr1328
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Fam83f
Name: family with sequence similarity 83, member F
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213956
VEGA: 15
Homologene: 16313
Prame62
Name: PRAME like 62
Synonyms: Gm12789
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381536
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Tmem171
Name: transmembrane protein 171
Synonyms: LOC380863
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380863
Homologene: 18301
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
Rragd
Name: Ras-related GTP binding D
Synonyms: 5730543C08Rik, D4Ertd174e, C030003H22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52187
Homologene: 49667
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103733
Homologene: 833
Taar8a
Name: trace amine-associated receptor 8A
Synonyms: LOC215859
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215859
Homologene: 77586
Vmn1r188
Name: vomeronasal 1 receptor 188
Synonyms: V1rh17
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 252912
Homologene: 110880
Snap23
Name: synaptosomal-associated protein 23
Synonyms: Syndet, SNAP-23, Sndt
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20619
Homologene: 37857
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68888
Homologene: 87422
Or6y1
Name: olfactory receptor family 6 subfamily Y member 1
Synonyms: GA_x6K02T2P20D-20731742-20730694, GA_x6K02SYWY4V-595-239, MOR103-13P, MOR103-17, EG546747, Olfr413-ps1, Olfr220
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 546747
Homologene: 67062
Cldn34c4
Name: claudin 34C4
Synonyms: 4930412D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73934
Homologene: 132184
Gm1988
Name: predicted gene 1988
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038967
Homologene: 80005
Gm21370
Name: predicted gene, 21370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100861977
VEGA: 13
Gm15956
Name: predicted gene 15956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,136,347 bp
  • T to A, chromosome 1 at 82,523,922 bp
  • G to C, chromosome 1 at 88,277,215 bp
  • T to A, chromosome 1 at 136,626,121 bp
  • A to G, chromosome 1 at 174,448,934 bp
  • T to C, chromosome 1 at 181,203,114 bp
  • A to G, chromosome 1 at 193,181,320 bp
  • A to G, chromosome 2 at 120,585,580 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • G to C, chromosome 3 at 88,643,878 bp
  • A to G, chromosome 3 at 96,919,152 bp
  • A to G, chromosome 3 at 108,217,676 bp
  • C to T, chromosome 4 at 33,007,155 bp
  • T to C, chromosome 4 at 40,260,794 bp
  • A to T, chromosome 4 at 101,988,329 bp
  • C to T, chromosome 4 at 118,934,033 bp
  • A to G, chromosome 5 at 17,785,720 bp
  • A to G, chromosome 5 at 66,022,737 bp
  • T to A, chromosome 5 at 103,965,854 bp
  • T to A, chromosome 5 at 109,091,546 bp
  • G to A, chromosome 5 at 120,675,609 bp
  • A to T, chromosome 5 at 135,132,527 bp
  • T to A, chromosome 6 at 47,866,225 bp
  • T to A, chromosome 6 at 57,404,735 bp
  • T to C, chromosome 6 at 70,726,458 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • A to G, chromosome 7 at 39,170,868 bp
  • A to G, chromosome 7 at 42,662,874 bp
  • A to T, chromosome 7 at 100,347,837 bp
  • T to C, chromosome 9 at 18,857,102 bp
  • T to A, chromosome 10 at 24,077,164 bp
  • A to G, chromosome 10 at 80,305,544 bp
  • T to G, chromosome 10 at 107,053,452 bp
  • A to G, chromosome 11 at 73,776,841 bp
  • T to C, chromosome 11 at 79,027,477 bp
  • T to A, chromosome 11 at 101,124,538 bp
  • T to C, chromosome 11 at 107,081,523 bp
  • T to C, chromosome 13 at 22,088,602 bp
  • A to T, chromosome 13 at 98,692,588 bp
  • A to G, chromosome 13 at 112,613,761 bp
  • A to G, chromosome 13 at 120,026,953 bp
  • T to A, chromosome 15 at 8,212,358 bp
  • T to C, chromosome 15 at 74,726,875 bp
  • A to T, chromosome 15 at 80,692,192 bp
  • T to C, chromosome 16 at 64,925,961 bp
  • T to C, chromosome 18 at 12,198,162 bp
  • A to G, chromosome 18 at 36,948,451 bp
  • A to G, chromosome 19 at 37,571,912 bp
  • A to T, chromosome X at 127,721,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4090 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040983-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.