Strain Name:
C57BL/6N-Tyrc-Wtsi/Mmucd
Stock Number:
041191-UCD
Citation ID:
RRID:MMRRC_041191-UCD
Major Collection:

Strain Information

Tyrc-Wtsi
Name: tyrosinase; albino Wellcome Trust Sanger Institute
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Spontaneous Mutation
Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mouse
Chromosome: 7
Alteration at locus: Spontaneous Mutation
NCBI: 22173
Homologene: 30969
Genetic Alterations
Spontaneous
Genotype Determination
The genotyping protocol for this strain is currently not available. The MMRRC will develop a protocol if this strain is ordered.
    ES Cell Line
    Not applicable
    Phenotype
    Phenotyping data may be available at mousephenotype.org.
    Mammalian Phenotype Terms
    Allelic Composition: Tyrc-Wtsi/Tyrc-Wtsi (Genetic Background: C57BL/6N-Tyrc-Wtsi/Wtsi )

    MeSH Terms
    • Albinism/genetics
    • Animals
    • Genome
    • Genomics
    • Genotype
    • Mice
    • Mice, Inbred C57BL/genetics
    • Mice, Transgenic
    • Monophenol Monooxygenase/deficiency
    • Monophenol Monooxygenase/genetics
    • Monophenol Monooxygenase/metabolism
    • Sequence Analysis, DNA
    Strain Development
    During routine colony expansion, a strain generated by the Sanger Mouse Genetics Project (MGP) EUCOMM ES cell clone EPD0176_3_A10 which carries the Stard7tm1a(EUCOMM)Wtsi allele produced albino mice from the first intercross of germline animals. A new colony of these mice was established from offspring selected to be wild-type for the Stard7tm1a(EUCOMM)Wtsi allele so the causal mutation could be identified. This new colony was backcrossed for 7 generations with C57BL/6NTac before being bred to homozygosity.
    Suggested Control Mice
    Wild-type littermates
    MMRRC Genetic QC Summary
    The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@ucdavis.edu. Older strains may not have this information.
    • Research Tools
    Donor
    Ramiro Ramirez-Solis, Ph.D., Wellcome Trust Sanger Institute.
    Primary Reference

    Ryder E, Wong K, Gleeson D, Keane TM, Sethi D, Vyas S, Wardle-Jones H, Bussell JN, Houghton R, Salisbury J, Harvey N, Adams DJ; Sanger Mouse Genetics Project, Ramirez-Solis R.Genesis. 2013 July; 51(7): 523-528. Genesis. 2013 Jul;51(7):523-8. (Medline PMID: 23620107)

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@ucdavis.edu.
    Coat Color
    Albino
    MMRRC Breeding System
    Backcross to C57BL/6NTac followed by Random intra-strain mating
    Breeding Scheme(s)
    • Wild-type female x Heterozygous male from the colony or reciprocal mating
    • Heterozygous female x Heterozygous male from the colony
    • Homozygous female x Homozygous male from the colony
    Generation
    N7
    Overall Breeding Performance
    Good
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Yes Yes
    Homozygotes are fertile: Yes Yes
    Heterozygotes are fertile: Yes Yes
    Age Reproductive Decline: 4 to 6 months 4 to 6 months
    Average litter size
    5-9
    Recommended wean age
    3-4 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

    Distribution of this strain requires execution of the MMRRC Sanger EUCOMM COU. A link to this form will be provided via email when an order is submitted; the PDF form should be downloaded or the email forwarded to the appropriate institutional representative for completion following directions in the document.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $)
    *Shipping & Handling not included*
    Units Notes
    041191-UCD-RESUS Litter recovered from cryo-archive $4,044.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

    1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.