Strain Detail Sheet

Strain Name:
FVB/N-Tg(tetO-Stat5a*S710F,-luc)11676Kuw/Mmmh
Stock Number:
042093-MU
Citation ID:
RRID:MMRRC_042093-MU
Other Names:
Tg(tetO-Stat5a*S710F,-luc)11676Kuw

Strain Information

Gene Details

Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20850
Homologene: 20680
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Tg(tetO-Stat5a*S710F,-luc)11676Kuw
Name: transgene insertion 11676, Kay-Uwe Wagner
Synonyms: TetO-Stat5(S710F)Flag-IRES-luciferase
Type: Transgene
Species: Mus musculus (mouse)
Chromosome:
Alteration at locus: Transgenic
Genetic Alterations
The tetracycline operator drives inducible expression of the FLAG-tagged mouse cDNA with a point mutation that results in an amino acid substitution of phenylalanine for serine at position 710 (S710F) and an IRES-luciferase reporter. Lines 11651 and 11676 were generated. see: MGI:5300600
Genotype Determination
ES Cell Line
Not specified

Strain Description

Phenotype

Homozygous: none

Hemizygous: none

Cre-excised Phenotype: undetermined

Strain Development
see MGI number 5300600 http://www.informatics.jax.org/allele/key/815309?page=alleleDetail&key=815309 The tetracycline operator drives inducible expression of the FLAG-tagged mouse cDNA with a point mutation that results in an amino acid substitution of phenylalanine for serine at position 710 (S710F) and an IRES-luciferase reporter. Lines 11651 and 11676 were generated.
Suggested Control Mice
Wild-type littermates

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Research Applications

  • Apoptosis
  • Cancer
  • Cell Biology
  • Developmental Biology
  • Hematology
  • Internal Organ
  • Models for Human Disease
  • Research Tools

Strain Origin

Donor
Kay-Uwe Wagner, Ph.D., University of Nebraska Medical Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
white
Other
please refer to MGI:5300600 for additional questions. there are no unusual characteristics. http://www.informatics.jax.org/allele/key/815309?page=alleleDetail&key=815309

Breeding

MMRRC Breeding System
Backcross
Generation
20+
Overall Breeding Performance
Excellent

Reproductive Statistics

NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Hetero/Hemizygotes are fertile: Yes Yes
Age Reproductive Decline: 8 to 12 months Greater than 12 months
Bred to Homozygosity
No
Average litter size
10-14
Recommended wean age
3-4 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.