Strain Name:
C57BL/6J-MtgxR5345Btlr/Mmmh
Stock Number:
042924-MU
Citation ID:
RRID:MMRRC_042924-MU
Other Names:
R5345 (G1), C57BL/6J-MtgxR5345Btlr
Major Collection:

Strain Information

Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: 9530039J15Rik, Centb2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Tak1-binding protein 1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, nonspecific lipid transfer protein, NSL-TP, ns-LTP, SCP-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156, MS2, E430039A18Rik, CD156a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Clca4a
Name: chloride channel accessory 4A
Synonyms: 9130020L07Rik, Clca6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Fbxw11
Name: F-box and WD-40 domain protein 11
Synonyms: HOS, BTRCP2, BTRC2, Fbxw1b, 2310065A07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103583
Homologene: 76444
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG, testis-enriched phosphatase, TEP, PTPMEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2, D930026N18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: NIMP, D10Ertd690e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170728
Homologene: 13105
Sec24c
Name: SEC24 homolog C, COPII coat complex component
Synonyms: 2610204K03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218811
VEGA: 14
Homologene: 3615
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Trbv12-1
Name: T cell receptor beta, variable 12-1
Synonyms: Gm16753, Tcrb-V5.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124672
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Coq8b
Name: coenzyme Q8B
Synonyms: 0610012P18Rik, Adck4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76889
Homologene: 86731
Acot1
Name: acyl-CoA thioesterase 1
Synonyms: D12Ucla1, CTE-1, ACH2, CTE-I, Cte1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26897
VEGA: 12
Homologene: 22686
Vwc2l
Name: von Willebrand factor C domain-containing protein 2-like
Synonyms: brorin-like, Brl, A830006F12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320460
Homologene: 27945
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: NGC, neuroglycan C, CALEB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Pkn1
Name: protein kinase N1
Synonyms: Pkn, PRK1, PAK1, Stk3, Prkcl1, F730027O18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Srsf9
Name: serine and arginine-rich splicing factor 9
Synonyms: SRp30c, 2610029M16Rik, Sfrs9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108014
Homologene: 20819
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76482
Homologene: 8341
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 171405
Homologene: 77136
Slc34a1
Name: solute carrier family 34 (sodium phosphate), member 1
Synonyms: renal Na+/Pi transporter, Na/Pi cotransporter, Slc17a2, Npt2, NaPi-IIa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20505
VEGA: 13
Homologene: 20663
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: P2x, RP-2, P2X1 receptor, Pdcd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Parl
Name: presenilin associated, rhomboid-like
Synonyms: PSENIP2, PRO2207, PSARL1, D16Ertd607e, Psarl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 381038
Homologene: 10239
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71609
Homologene: 2807
Cenpo
Name: centromere protein O
Synonyms: D12Ertd482e, 8430427C03Rik, 2810429O05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52504
Homologene: 49760
Tsga10
Name: testis specific 10
Synonyms: 4933432N21Rik, Mtsga10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211484
Homologene: 23531
Ripply2
Name: ripply transcriptional repressor 2
Synonyms: LOC382089, C030002E08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382089
Homologene: 19960
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Sgcg
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms: gamma-SG, 5430420E18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24053
Homologene: 194
Cdc25b
Name: cell division cycle 25B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12531
HGNC: HGNC:1726
Homologene: 41451
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 5330407H02Rik, 4930471A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Or2l13b
Name: olfactory receptor family 2 subfamily L member 13B
Synonyms: GA_x54KRFPKG5P-15979009-15978071, MOR271-1, Olfr168
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258354
Homologene: 128057
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545288
Homologene: 74936
Or5aq1b
Name: olfactory receptor family 5 subfamily AQ member 1B
Synonyms: GA_x6K02T2Q125-48565383-48564445, MOR172-2, Olfr1107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258841
Homologene: 131138
Msantd5f6
Name: Myb/SANT DNA binding domain containing 5 family member 6
Synonyms: Gm11487
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433719
Homologene: 128423
Or10g3
Name: olfactory receptor family 10 subfamily G member 3
Synonyms: GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258424
HGNC: HGNC:8171
Homologene: 27165
Ndufb4
Name: NADH:ubiquinone oxidoreductase subunit B4
Synonyms: 0610006N12Rik, 1300010H20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68194
HGNC: HGNC:7699
Homologene: 3342
Rps4l-ps
Name: ribosomal protein S4-like, pseudogene
Synonyms: Gm6816
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627967
Gm27013
Name: predicted gene, 27013
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Tcstv5a
Name: Tcstv family member 5A
Synonyms: Tcstv5, B020031M17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 333467
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,763,311 bp
  • T to C, chromosome 1 at 60,328,210 bp
  • A to G, chromosome 1 at 70,728,918 bp
  • A to G, chromosome 1 at 72,670,151 bp
  • A to G, chromosome 1 at 119,765,477 bp
  • A to G, chromosome 1 at 127,390,831 bp
  • T to C, chromosome 2 at 25,016,546 bp
  • T to A, chromosome 2 at 31,797,047 bp
  • A to G, chromosome 2 at 49,723,066 bp
  • A to G, chromosome 2 at 87,071,492 bp
  • A to G, chromosome 2 at 131,192,596 bp
  • A to C, chromosome 3 at 31,223,857 bp
  • T to G, chromosome 3 at 144,970,461 bp
  • A to T, chromosome 4 at 73,401,277 bp
  • A to T, chromosome 4 at 108,055,579 bp
  • A to C, chromosome 4 at 128,588,121 bp
  • A to T, chromosome 4 at 148,038,749 bp
  • A to G, chromosome 5 at 115,330,536 bp
  • A to G, chromosome 5 at 121,263,974 bp
  • C to T, chromosome 6 at 41,113,847 bp
  • A to G, chromosome 6 at 118,656,536 bp
  • A to C, chromosome 6 at 130,520,794 bp
  • A to G, chromosome 7 at 27,250,348 bp
  • T to C, chromosome 7 at 114,927,198 bp
  • A to G, chromosome 7 at 139,987,639 bp
  • A to G, chromosome 8 at 83,677,810 bp
  • A to T, chromosome 8 at 105,259,924 bp
  • A to G, chromosome 9 at 87,019,726 bp
  • T to C, chromosome 9 at 108,832,124 bp
  • A to T, chromosome 9 at 110,246,630 bp
  • T to C, chromosome 10 at 23,110,048 bp
  • T to C, chromosome 10 at 43,932,470 bp
  • T to A, chromosome 10 at 94,849,969 bp
  • A to G, chromosome 11 at 23,742,462 bp
  • A to G, chromosome 11 at 32,738,471 bp
  • C to T, chromosome 11 at 42,626,809 bp
  • A to G, chromosome 11 at 60,497,538 bp
  • A to G, chromosome 11 at 73,009,230 bp
  • C to T, chromosome 11 at 117,723,287 bp
  • A to G, chromosome 12 at 4,214,611 bp
  • T to C, chromosome 12 at 4,672,783 bp
  • T to A, chromosome 12 at 84,017,168 bp
  • A to T, chromosome 13 at 46,686,865 bp
  • A to G, chromosome 13 at 55,400,518 bp
  • A to T, chromosome 13 at 119,949,848 bp
  • T to A, chromosome 14 at 20,693,220 bp
  • G to A, chromosome 14 at 52,372,268 bp
  • A to T, chromosome 14 at 61,245,769 bp
  • T to A, chromosome 15 at 76,911,495 bp
  • A to T, chromosome 15 at 80,149,813 bp
  • T to G, chromosome 15 at 81,623,452 bp
  • T to A, chromosome 16 at 19,530,777 bp
  • A to T, chromosome 16 at 20,298,142 bp
  • A to G, chromosome 16 at 31,108,126 bp
  • A to G, chromosome 16 at 37,654,178 bp
  • A to G, chromosome 17 at 67,817,563 bp
  • C to T, chromosome 18 at 12,179,177 bp
  • T to C, chromosome 18 at 31,648,198 bp
  • C to G, chromosome 19 at 7,865,938 bp
  • T to A, chromosome 19 at 39,626,232 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5345 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042924-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.