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MAP3K14 (NIK) knockout, NIK-/-
Two intronic loxP sites were inserted into the Map3k14 gene, one upstream of the ATG start codon and one downstream of exon 5. Subsequent breeding to a Cre deleter strain excised the enveloped exons.
The floxed allele was generated with ES cells derived from 129Sv. NIK+/- mice were generated by crossing NIKfl/fl mice with B6.FVB-Tg(EIIa-cre)C5379Lmgd/J (RRID:IMSR_JAX:003724). The EIIa-cre allele was removed by breeding with C57BL/6J mice over 6 generations.
Liu Y, Sheng L, Xiong Y, Shen H, Liu Y, Rui L. Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity. Endocrinology. 2017 May 1;158(5):1207-1216. doi: 10.1210/en.2016-1582. (Medline PMID: 28379340)
Xiong Y, Torsoni AS, Wu F, Shen H, Liu Y, Zhong X, Canet MJ, Shah YM, Omary MB, Liu Y, Rui L. Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife. 2018 Aug 2;7:e34152. doi: 10.7554/eLife.34152. (Medline PMID: 30070632)
Shen H, Sheng L, Xiong Y, Kim YH, Jiang L, Chen Z, Liu Y, Pyaram K, Chang CH, Rui L. Thymic NF-κB-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol. 2017 Jul;67(1):100-109. doi: 10.1016/j.jhep.2017.02.025. Epub 2017 Mar 6. (Medline PMID: 28267623)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.