On a B6 background, homozygous mutant animals are not recovered with Mendelian ratios, suggesting loss during embryogenesis, early post-natal. Homozygous mutants are often runted, females display loss of oocytes from ovary and preneoplastic transformation of ovarian surface epithelium.
On 129S4 background, MMRRC:009984, males and females have problems with eyes - microphthalmia and lacrimal gland problems.
On B6;129S4 hybrid background, males are sterile due to loss of germ cells and Sertoli cells from testis.
Mammalian Phenotype Terms:(provided by MGI)Extend all MPTs assigned by genotype
The following phenotype information may relate to one or more alleles on a genetic background differing from this MMRRC strain.
endocrine/exocrine gland phenotype
abnormal seminiferous tubule morphology (MGI Ref ID J:46386)
tubules are devoid of germ cells by 6 months of age
by 8 months of age most sertoli cells had sloughed off and there was reduction in the number of leydig cells
decreased seminal vesicle weight (MGI Ref ID J:46386)
progressive weight reduction after 5 months of age, resulting in weights 10% those of normal at 14 months of age
Grant MacGregor, Ph.D., University of California, Irvine.
Ross AJ, Waymire KG, Moss JE, Parlow AF, Skinner MK, Russell LD, MacGregor GR. Testicular degeneration in Bclw-deficient mice. Nat Genet. 1998 Mar;18(3):251-6. (Medline PMID: 9500547).
Colony and Husbandry Information
Coat color: Black
MMRRC Breeding System: Backcross
C57BL/6 female x Heterozygous male or reciprocal mating
Generation: N12 (when donated)
Overall Breeding Performance: Excellent
Viability and Fertility:
Homozygotes are viable:
Homozygotes are fertile:
Heterozygotes are fertile:
Age Reproductive Decline:
Average litter size: 8-10
Recommended wean age: 3 weeks
Health Status Report
Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email firstname.lastname@example.org.
Order Request Information
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Conditions of Distribution:
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU).
A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded
to your institutional official for completion.
Additional charges may apply for any special requests. Shipping
costs are in addition to the basic distribution/resuscitation
fees. Information on shipping costs and any additional charges will be provided
by the supplying MMRRC facility.
Click button to Request this one strain.
(Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item #
Fee/unit (US $)
Litter recovered from cryo-archive
$2,022.00 / $4,109.00
Non-Profit / For-Profit
Recovered litter1; additional fees for any special requests.
$437.00 / $817.00
Non-Profit / For-Profit
The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
An aliquot contains a sufficient number of embryos (in one or more
vials and based on the transfer success rate of the MMRRC facility) to
transfer to at least two recipients. The MMRRC makes no guarantee concerning
embryo transfer success experienced in the recipient investigator's laboratory.
Neither gender nor genotype ratios are guaranteed.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the "Request this Strain" button above). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.
The MMRRC is a collaborative effort, funded by grants from the